In Vivo Success of Trypanosoma cruzi is Regulated by Host Cell | |||||||
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报告题目: In Vivo Success of Trypanosoma cruzi is Regulated by Host Cell Type and Parasite Sensing of Host Cell Health 报告人: 张巍波 博士 报告地点: 动医动科大楼 B110 室 报告时间: 5月5日(星期四)上午11: 00-12: 00 : 索 勋 教授 联系人
报告人简介: 张巍波,美国乔治亚大学微生物学博士。研究方向为枯氏锥虫病弱毒活疫苗及枯氏锥虫病疫苗免疫后免疫优势MHC I类限制性抗原表位的鉴定。 EDUCATION • University of Georgia, Athens, Georgia, USA. Doctor of Philosophy, microbiology, 2009 – 2015 • Beijing Institute of Technology, Beijing, China. Bachelor of Science, biotechnology, 2005 - 2009 PUBLICATION 1. Zhang W.; Tarleton RL. Trypanosoma cruzi Calreticulin Promotes Infection of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1)-Expressing Phagocytes. Manuscript prepared for Submission. 2. Rosenberg CS.; Zhang W.; Bustamante JM; Tarleton RL. Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant Trans-Sialidase-Specific CD8+ T Cells. Submitted. Infection and Immunity. 3. Zhang, W.; Miao Y.; Feng Y. The Effects of Symplasmata Structure of Pantoea agglomerans YS19 on Thallus Resistance against Unfavorable Circumstances. Journal of Microbiology, 2009, 29 (1): 12-17. ACADEMIC AWARDS 1. Provincial and Ministry level – Grand prize, Beijing Challenge Cup (natural science), 2009 2. University level - Grand Prize, Challenge Cup (natural science), 2009 RESEARCH (University of Georgia) Project 1: Developing recombinant protein-based, synthetic peptide-based, mouse cell line based, high throughput methods for identification of subdominant Class I MHC restricted epitopes during infection with the protozoan pathogen Trypanosoma cruzi in the goal of eliciting optimized CD8+ T cell response in mice vaccinated with live attenuated T. cruzi strains Project 2: Constructing a live attenuated T. cruzi vaccine strain overexpressing calreticulin and Characterizing the immune responses and protection efficiency of the vaccine candidate against T. cruzi challenge in mice,University of Georgia, Athens, Georgia, USA. Project 3: Identifying the interaction between Trypanosoma cruzi PAMP molecule, calreticulin and the receptor low-density lipoprotein receptor-related protein 1 on phagocytes and investigating the impact of this interaction on immune responses and pathogen control during infection Project 4: Identifying and characterizing the role of a previously uncharacterized, trypanosomatid-specific, flagellar membrane protein during T. cruzi infection in vitro and in vivo Advisor: Rick L. Tarleton, distinguished professor, Department of Cellular Biology 欢迎老师和同学参加!
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