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6月8日学术报告:Nucleotide Excision Repair In Vivo:DNA Damage and Repair Maps of the Human Genome

农业生物技术国家重点实验室学术报告

Nucleotide Excision Repair In Vivo:

DNA Damage and Repair Maps of the Human Genome

主讲: 胡晋川 博士

北卡大学医学院生物化学与生物物理系 

Aziz Sancar 教授(2015年诺贝尔化学奖获得者)实验室

电子邮箱: jinchuan@email.unc.edu


2017年6月8日 周四上午10:00-11:00am

生命科学中心2018会议室

报告人简介


RESEARCH AND PROFESSIONAL EXPERIENCE


2012.6-present Research Associate, Department of Biochemistry and Biophysics, University of North Carolina School of Medicine. 

EDUCATION


2004-2012     Ph.D. in Molecular Biology and Biochemistry

Institute of Microbiology, Chinese Academy of Sciences, China

2000-2004     B.S. in Biological Sciences,

College of Life Sciences, Peking University, China

PUBLICATIONS


Hu J*, Adebali O*, Adar S, and Sancar A. Dynamic maps of UV damage formation and repair for the human genome. Proc Natl Acad Sci U S A. 2017, accepted.

Hu J, Lieb JD, Sancar A, and Adar S. Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution. Proc Natl Acad Sci U S A. 2016, 113(41):11507-11512 (Research Highlight In This Issue)

Adar S*, Hu J*, Lieb JD, and Sancar A. Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis. Proc Natl Acad Sci U S A. 2016, 113(15): E2124-E2133

Hu J*, Adar S*, Selby CP, Lieb JD, and Sancar A. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes & Development. 2015, 29(9): 948-960. (Research Highlight In This Issue)

Hu J, Choi JH, Gaddameedhi S, Kemp MG, Reardon JT, Sancar A. Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo. J Biol Chem. 2013, 288(29): 20918–20926.

Hu J, Guo L, Wu K, Liu B, Lang S, Huang L. Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus. Nucleic Acids Res. 2012, 40(8): 3470-3483.

Hu J, Adar S. The Cartography of UV-induced DNA Damage Formation and DNA Repair. Photochem Photobiol. 2017, 93 (1): 199-206 Review.

Li W, Hu J, Adebali O, Adar S, Yang, Y, Chiou, YY, and Sancar A. General method for genome-wide mapping of nucleotide excision repair: application to UV and benzo[a]pyrene-induced DNA damage. Proc Natl Acad Sci U S A. 2017, accepted.

Adebali O, Chiou YY, Hu J, Sancar A, Selby CP. Genome-wide Transcription-coupled Repair in E. coli is Mediated by Mfd Protein. Proc Natl Acad Sci U S A. 2017, 114(11): E2116–E2125.

Kemp MG and Hu J. Post-excision Events in Human Nucleotide Excision Repair. Photochem Photobiol. 2017, 93 (1): 178-191 Review.

Canturk F, Karaman M, Selby CP, Kemp MG, Kulaksiz-Erkmen G, Hu J, Li W, Lindsey-Boltz LA, and Sancar A. Nucleotide excision repair by dual incisions in plants. Proc Natl Acad Sci U S A. 2016, 113(17):4706-10

Lindsey-Boltz LA, Kemp MG, Hu J, Sancar A. Analysis of ribonucleotide removal from DNA by human nucleotide excision repair. J Biol Chem. 2015, 290(50): 29801-7.

Sancar A, Lindsey-Boltz LA, Gaddameedhi S, Selby CP, Ye R, Chiou YY, Kemp MG, Hu J, Lee JH, and Ozturk N. Circadian Clock, Cancer, and Chemotherapy. Biochemistry, 2015, 54(2): pp 110–123.

Kemp MG, Gaddameedhi S, Choi JH, Hu J and Sancr A. DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair. J Biol Chem. 2014, 289(38): 26574-26583. 

Choi JH, Gaddameedhi S, Kim SY, Hu J, Kemp MG, Sancar A. Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells. Nucleic Acids Res. 2014, 42(4): e29.

Liu Y*, Guo L*, Guo R, Wong RL, Hernandez H, Hu J, Chu Y, Amster IJ, Whitman WB, Huang L. The Sac10b homolog in Methanococcus maripaludis binds DNA at specific sites. J. Bacteriol. 2009, 191(7): 2315-29.

Wu K, Lai X, Guo X, Hu J, Xiang X, Huang L, Interplay between primase and replication factor C in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 2007, 63(3):826-37.

CONFERENCES

2016, NCI Symposium on Chromosome Biology: Nuclear Structure, Genome Integrity and Cancer, Bethesda, MD, USA, poster

2016, Gordon Research Conference on DNA Damage, Mutation & Cancer, Ventura, CA, USA, poster

2016, Gordon Research Seminar on DNA Damage, Mutation & Cancer, Ventura, CA, USA, poster and selected oral presentation

2015, Epigenetics in Development, Aging and Disease Symposium, Chapel Hill, NC, USA, poster

2015, NCI Symposium on Chromosome Biology, Bethesda, MD, USA, poster

2013, NIH-DNA Repair Video Conference Young Investigator Talk, USA (Only three people were selected each year, video link: http://videocast.nih.gov/Summary.asp?File=18017&bhcp=1)

2011, Sino-Danish Archaea Biology and Biotechnology Symposium, Wuhan, China, poster


AWARDS & HONORS


2015, Joseph S. Pagano Award of UNC Lineberger Comprehensive Cancer Center

2015, Postdoctoral Award for Research Excellence of University of North Carolina at Chapel Hill (Only 10 postdoctoral scholars in all disciplines in UNC were selected for this award each year)

2012, Excellent Graduates of Beijing's Colleges and Universities

2012, Excellent Graduates of Graduate University of the Chinese Academy of Sciences (CAS)

2012, CAS President Award (top award for graduate student of CAS)

2012, Chair Award of Institute of Microbiology

2009, Outstanding Student of CAS


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