报告题目:小鼠皮层神经元出生后发育以及成熟机制的研究 报告人:袁文 博士(Harvard University) 报告时间:2018年4月2日(周一) 下午14:30-16:00 报告地点:生命科学大楼2018会议室 欢迎各位老师同学踊跃参加! 袁文博士简介 袁文,现为美国哈佛大学干细胞和再生医学系博士后,主要以模式动物为研究对象从事表观遗传学研究以及神经元特性维持的分子机制探索。其研究主要聚焦于控制大脑皮层神经元不同亚型的发展机制,以及在皮质输出电路缺陷导致的神经退行性疾病和外伤性疾病背景下开发帮助神经元再生的治疗方法。目前已在国际著名杂志Science、Cell Research、Nature Neuroscience、JBC等上发表多篇高质量研究论文。 教育和工作背景 2012-至今 美国哈佛大学 博士后 2010-2012 北京生命科学研究所 博士后 2005-2010 北京生命科学研究所 博士 2003-2005 中国科学院遗传与发育研究所 助理研究员 1999-2003 中国农业大学生物学院 学士 发表文章 1, Wen Yuan, Jingwei Xie, Chengzu Long, Hediye Erdjument-Bromage, Xiaojun Ding, Yong Zheng. Paul Tempst, She Chen, Bing Zhu, and Danny Reinberg. Heterogeneous Nuclear Ribonucleoprotein L Is a Subunit of Human KMT3a/Set2 Complex Required for H3 Lys-36 Trimethylation Activity in Vivo.The Journal of Biological Chemistry, 284, 15701-15707. June 5, 2009. 2, Guangshuai Jia, Weixiang Wang, Hong Li, Zhuo Mao, Gaihong Cai, Jian Sun, Hui Wu, Mo Xu, Peng Yang, Wen Yuan, She Chen and Bing Zhu. A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions. Cell Research (2009) 19:1217–1220. doi:10.1038/cr.2009.110 3, Wen Yuan, Tong Wu, Hang Fu, Chao Dai, Hui Wu, Nan Liu, Xiang Li, Mo Xu, Zhuqiang Zhang, Tianhui Niu, Zhifu Han, Jijie Chai, Xianghong Jasmine Zhou, Shaorong Gao, Bing Zhu. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 Lysine 27 methylation Science 2012; 337: 971 (Perspective by Dr. Vincenzo Pirrotta in Science) 4, Wen Yuan, Mo Xu, Chang Huang, Nan Liu, She Chen, Bing Zhu.H3K36 methylation antagonizes PRC2 mediated H3K27 methylation.The Journal of Biological Chemistry. January 14, 2011, doi: 10.1074/jbc.M110.194027 (Best Papers of 2011 in JBC) 5, Gang Yuan, Ben Ma, Wen Yuan, Zhuqiang Zhang, Ping Chen, Xiaojun Ding, Li Feng, Xiaohua Shen, She Chen, Guohong Li, Bing Zhu. Histone H2A ubiquitination inhibits the enzymatic activity of H3 Lysine 36 methyltransferases.J Biol Chem, 2013. PMID: 24019522 6, Simona Lodato, Bradley J Molyneaux, Emanuela Zuccaro, Loyal A Goff, Hsu-Hsin Chen, Wen Yuan, Alyssa Meleski, Emi Takahashi, Shaun Mahony, John L Rinn, David K Gifford & Paola Arlotta Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons Nature Neuroscience 17, 1046–1054 (2014) doi:10.1038/nn.3757 |