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侯健
发布日期：2018-09-14 浏览次数：　　信息来源：生物学院

教师简介

姓名：侯健            
性别：男
系别：动物学与动物生理学
职称：副教授
学位：博士









侯健 博士，副教授，博士生导师。现于中国农业大学生物学院动物生理系和农业生物技术国家重点实验室从事科研教学工作。

 

学习与工作经历

2006.1至今：中国农业大学生物学院，副教授

2001.7-2005.12：中国农业大学生物学院，讲师

1998.9-2001.6：中国农业大学生物学院生理学专业，博士研究生

1995.9-1998.6：内蒙古农业大学动物遗传与繁育专业，硕士研究生

1991.9-1995.6：内蒙古农业大学畜牧专业，本科

 

研究方向

动物胚胎发育与表观遗传学，包括卵泡发育、卵子成熟、受精和胚胎发育等过程中的遗传学与表观遗传学调控机制研究。

动物胚胎工程技术，包括同期发情、超数排卵、体外受精、胚胎冷冻、胚胎移植、胚胎克隆、基因编辑等技术的研究与开发应用。

 

主讲课程

《基因打靶》（本科生）


联系方式

电话：62733355-17
邮件：houjian at cau.edu.cn
通讯地址：北京市海淀区圆明园西路2号中国农业大学生命科学楼58号

 

发表文章

  1. Wang Q, Zhang Y, Zhong X, Li J, An X, Hou J. Dimethylated histone H3 lysine 9 is dispensable for the interaction between developmental pluripotency-associated protein 3 (Dppa3) and ten-eleven translocation 3 (Tet3) in somatic cells. Reproduction, Fertility and Development, 2018, online.

  2. Zhang Y, Gao E, Wang Q, Tian H, Hou J.Effects of histone methyltransferase inhibitor chaetocin on histone H3K9 methylation of cultured ovine somatic cells and development of preimplantation cloned embryos. Reproductive Toxicology, 2018, online.

  3. Zhang Y, Wang Q, Liu K, Gao E, Guan H, Hou J.Treatment of donor cells with recombinant KDM4D protein improves preimplantation development of cloned ovine embryos. Cytotechnology, 2018, online.

  4. Zhong X, Wang Q, LI J, Zhang Y, An X, Hou J.Ten-eleven translocation-2 (Tet2) is involved in myogenic differentiation of skeletal myoblast cells in Vitro. Scientific Reports. 2017, 7, 43539

  5. Zhang N, Li J, Zhong X, An X, Hou J. Reversible immortalization of sheep fetal fibroblast cells by tetracycline-inducible expression of human telomerase reverse transcriptase. Biotechnology Letters, 2016, 38:1261-1268.

  6. Fu L, Yan F, An X, Hou J. Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos. Reproduction in Domestic Animals, 2014, 49: e21-e25.

  7. Fu L, Zhang J, Yan F, Guan H, An X, Hou J. Abnormal histone H3K9 dimethylation but normal dimethyltransferase EHMT2 expression in cloned sheep embryos. Theriogenology, 2012, 78:1929-1938.

  8. Li Q, Hou J, Wang S, Chen Y, An X. Production of transgenic rabbit embryos through intracytoplasmic sperm injection. Zygote, 2010, 18:301-307.

  9. Li Q, Hou J, Chen Y, An X. Full term development of rabbit embryos produced by ICSI with sperm frozen in liquid nitrogen without cryoprotectants. Reproduction in Domestic Animal, 2010, 45:717-722.

  10. Li Q, Hou J, Wang S, Guan H, Zhang N, Chen Y, An X. Viable rabbits derived from oocytes by intracytoplasmic injection of spermatozoa from an infertile male. Zygote, 2009,17:157-162.

  11. Hou J, Liu L, Zhang J, Cui XH, Yan F, Guan H, Chen Y, An X. Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation. BMC Developmental Biology 2008, 8:60.

  12. Liu L, Hou J, Lei T, Bai J, Guan H, An X. Aberrant DNA methylation in cloned ovine embryos. Chinese Science Bulletin, 2008, 53: 477-480.

  13. Bai J, Hou J, Guan H, Yan F, Cui X, Liu L, Wang S, An X. Effect of 2-mercaptoethanol and cysteine supplementation during in vitro maturation on the developmental competence of oocytes from hormone-stimulated lambs. Theriogenology, 2008, 70: 758-764.

  14.  Cui W, Ren L, Hou J, Zhang Y, Chen Y, An X. A model study: simulation of marker gene deletion and target gene replacement mediated by Cre/lox system in cell line. Progress in Biochemistry and Biophysics, 2008, 35: 650-660.

  15.  Li Q, Guan H, Hou J, An X, Chen Y. Transfer of ovine embryos through a simplified mini-laparotomy technique. Journal of Animal Science, 2008, 86: 3224-3227.

  16. Hou J, Liu L, Lei T, Cui X, An X, Chen Y. Genomic DNA methylation patterns in bovine preimplantation embryos derived from in vitro fertilization. Sciences in China (Series C), 2007, 50:56-61.

  17. Hou J, Lei T, Liu L, Cui X, An X, Chen Y. Demecolcine-induced enucleation of sheep meiotically maturing oocyes. Reproduction, Nutrition and Development. 2006, 46: 219－226.

  18. Hou J, Lei T, Liu L, Cui X, An X, Chen Y. DNA methylation patterns in in vitro-fertilised goat zygotes. Reproduction, Fertility and Development. 2005, 17: 809-813.

  19. Hou J, Cui X, Lei T, Liu L, An X, Chen Y. Aberrant DNA methylation patterns in cultured mouse embryos. Progress in Natural Science. 2005, 15:1079－1083.

  20. Gou K, An X, Guan H, Yang X, Hou J, Lin A, Zeng S, Chen Y. Transgenic twin lambs cloned by granulose cells. Cloning and Stem Cells. 2003,5:71-78.

论著： 《生物技术概论》，副主编，中国农业大学出版社，2010年第一版

 

获奖情况

  1. 国家现代农业产业技术体系建设项目, 2016-2020，在研，主持

  2. 畜禽繁殖调控新技术研发,国家重点研发计划项目，2017-2020，在研，任务主持

  3. 转座子介导安全高效基因编辑技术研究，转基因新品种培育重大专项，2018-2019，在研，任务主持

  4. 主要转基因动物和饲料安全性检测及安全控制关键技术引进，农业部948计划项目，2016-2018，在研，任务主持.

  5. 羟甲基胞嘧啶及TET蛋白在早期胚胎DNA去甲基化过程中的作用机制研究，国家自然科学基金面上项目，2012-2015，已结题，主持。

  6. 可逆型长寿细胞构建及用于绵羊体细胞基因打靶的研究，国家自然科学基金面上项目2011-2013，已结题，主持。

  7. DNA甲基化酶和组蛋白甲基化酶在绵羊体细胞克隆胚胎中的表达研究，国家自然科学基金青年基金项目，2008-2010，已结题，主持。

  8. 转基因猪、牛和羊的环境安全评价技术，转基因新品种培育重大专项：,2011-2013，已结题，参加。

  9. 转基因肉羊新品种培育，转基因新品种培育重大专项，2008-2010，已结题，子任务主持。

 

专利情况

1. 一种诱导动物体外细胞可逆永生化的载体及其应用，专利号201310692377.3

2. 一种用于诱导表达锌指核酸酶的载体及其应用，专利号201310692299.7

 

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