教师简介

姓名：	侯云鹏
性别：	男
系别：	动物学与动物生理学
职称：	副教授
学位：	博士

侯云鹏 博士，副教授，博士生导师。2008年12月至今，任中国农业大学生物学院副教授，主要研究哺乳动物（猪、牛和鼠）卵母细胞成熟和发育的钙稳态调节机理，环境与药物对生殖生理的干扰影响。

学习与工作经历

2006/07－至今，中国农业大学生物学院，讲师、副教授

2001/09－2006/06，中国农业大学动物科技学院，农学博士学位

1994/09－1998/06，中国农业大学动物科技学院，农学学士学位

研究方向

大量研究证实[Ca2+]i在卵母细胞减数分裂，激活，受精及早期胚胎发育过程中起着重要的调控作用，其稳态的维持对于卵母细胞正常机能至关重要。本人主要通过分子生物学、细胞生物学和生物化学等手段，研究哺乳动物（猪、牛和鼠）卵母细胞钙稳态调节机理，为生殖生物学提供理论支撑，为动物生物技术研究提供充足的卵母细胞资源。（一）以卵母细胞膜为研究材料，系统研究膜上蛋白识别调控钙离子出入的生理及分子机制；（二）以胞质、内质网和线粒体为研究材料，通过调节钙库中钙离子释放和收集研究卵母细胞生理变化机制，及其对未来胚胎重编程及发育的影响；（三）以雌性小鼠为研究材料，通过体内饲喂或体外培养体系中添加药物或环境中有毒有害物质，研究药物和环境对雌性生殖生理干扰及机制。

主讲课程

《探索生命的奥秘》（一年级本科生）、《生物学方法论》（二/三年级本科生）和《生物产业与就业》（四年级本科生）。

联系方式

办公电话：010-62734166 
邮件：hou at cau.edu.cn
通讯地址：北京市海淀区圆明园西路2号中国农业大学西校区生命科学研究中心96号信箱，100193

发表文章 (# Equal Contribution, * Corresponding Author)

(1) The Role of Ca2+ in Maturation and Reprogramming of Bovine Oocytes: A System Study of Low-Calcium Model

Authors (9): Meng, Lin^#; Hu, Hongmei^#...Hou, Yunpeng*

Published: Oct 2021in Frontiers in Cell and Developmental Biology

DOI: 10.3389/FCELL.2021.746237

(2) Polystyrene Microplastics Induced Female Reproductive Toxicity in Mice

Authors (6): Zhiqiang Liu; Qingrui Zhuan ... Yunpeng Hou*

Published: Oct 2021in Journal of Hazardous Materials

DOI: 10.1016/J.JHAZMAT.2021.127629

(3) Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca2+ entry

Authors (8): Lu Yao Zhang^#; Meng Lin^#... Hou, Yunpeng*

Published: Sep 2021in Cell Proliferation

DOI: 10.1111/CPR.13127

(4) The Calcium-Sensing Receptor Is Involved in Follicle-Stimulating HormoneInduced Cumulus Expansion in in vitro Cultured Porcine Cumulus-Oocyte Complexes

Authors (8): Liu, Huage^#; Zhou, Dan^#... Hou, Yunpeng*

Published: May 2021in Frontiers in Cell and Developmental Biology

DOI: 10.3389/FCELL.2021.625036

(5) Mitochondrial Ca2+ Overload Leads to Mitochondrial Oxidative Stress and Delayed Meiotic Resumption in Mouse Oocytes

Authors (7): Zhang, Luyao; Wang, Zichuan ... Hou, Yunpeng*

Published: Dec 2020in Frontiers in Cell and Developmental Biology

DOI: 10.3389/FCELL.2020.580876

(6) Dihydroartemisinin exposure impairs porcine ovarian granulosa cells by activating PERK-eIF2 alpha-ATF4 through endoplasmic reticulum stress

Authors (7): Luo, Yan; Guo, Qing ... Hou, Yunpeng*

Published: Sep 2020in Toxicology and Applied Pharmacology

DOI: 10.1016/J.TAAP.2020.115159

(7) The extracellular calcium-sensing receptor promotes porcine egg activation via calcium/calmodulin-dependent protein kinase II

Authors (8): Liu, Cong; Liu, Huage ... Hou, Yunpeng*

Published: May 2020in Molecular Reproduction & Development

DOI: 10.1002/MRD.23322

(8) Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the reproduction of female mice

Authors (5): Liu, Huage; Liu, Zhiqiang ... Hou, Yunpeng*

Published: Nov 2019in Ecotoxicology and Environmental Safety

DOI: 10.1016/J.ECOENV.2019.109544

(9) Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the maturation and subsequent development of murine oocyte

Authors (7): Liu, Huage; Liu, Zhiqiang ... Hou, Yunpeng*

Published: Oct 2019in Ecotoxicology and Environmental Safety

DOI: 10.1016/J.ECOENV.2019.06.006

(10) Toxicity and related mechanisms of dihydroartemisinin on porcine oocyte maturation in vitro

Authors (6): Luo, Yan; Che, Man-Ju ... Hou, Yunpeng*

Published: Feb 2018in Toxicology and Applied Pharmacology

DOI: 10.1016/J.TAAP.2018.01.002

(11) BAPTA-AM dramatically improves maturation and development of bovine oocytes from grade-3 cumulus-oocyte complexes

Authors (5): Hu, Hongmei; Mo, Xianhong ... Hou, Yunpeng*

Published: Jan 2018in Molecular Reproduction & Development

DOI: 10.1002/MRD.22936

(12) Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice

Authors (6): Zhao, Lihong; Lu, Tengfei ... Hou, Yunpeng*

Published: Aug 2017in Journal of Animal Science and Biotechnology

DOI: 10.1186/S40104-017-0195-Z

(13) The Extracellular Calcium-Sensing Receptor (CASR) Regulates GonadotropinsInduced Meiotic Maturation of Porcine Oocytes

Authors (8): Liu, Cong; Wu, Guo-Quan ... Hou, Yunpeng*

Published: Dec 2015in Biology of Reproduction

DOI: 10.1095/BIOLREPROD.115.128579

(14) Leukemia Inhibitory Factor Enhances Bovine Oocyte Maturation and Early Embryo Development

Authors (7): Mo, Xianhong; Wu, Guoquan ... Hou, Yunpeng*

Published: Jul 2014in Molecular Reproduction & Development

DOI: 10.1002/MRD.22327

(15) Nuclear maturation and embryo development of porcine oocytes vitrified by cryotop: Effect of different stages of in vitro maturation

Authors (7): Wu, Guoquan; Jia, Baoyu ... Hou, Yunpeng*

Published: Aug 2013in Cryobiology

DOI: 10.1016/J.CRYOBIOL.2013.05.010

(16) Decreased Expression of CD9 in Bovine Oocytes After Cryopreservation and the Relationship to Fertilization Capacity

Authors (8): Zhou, Guang-Bin^#*; Zeng, Yan^#... Hou, Yun-Peng*

Published: Jun 2013in Molecular Reproduction & Development

DOI: 10.1002/MRD.22181

(17) Improved parthenogenetic development of vitrified-warmed bovine oocytes activated with 9% ethanol plus 6-DMAP

Authors (9): Hou, Y. -P.; Liu, Y. ... Zhu, S. -E.

Published: Sep 2009in Theriogenology

DOI: 10.1016/J.THERIOGENOLOGY.2009.04.020

(18) Bovine oocytes vitrified by the open pulled straw method and used for somatic cell cloning supported development to term

Authors (12): Hou, YP; Dai, YP ... Li, N

Published: Oct 2005in Theriogenology

DOI: 10.1016/J.THERIOGENOLOGY.2005.03.012

获奖情况

2007年获得北京市青年科技论文一等奖

2013年获得北京市高等教育教学成果奖二等奖（3/6）

承担项目及课题

1. 国家科技重大专项，30972101，MSTN敲除肉牛营养与饲养管理，2016/01-2020/12，已结题，主持。

2. 国家科技重大专项，2013ZX08007002-002，MSTN敲除肉牛生产及生物安全评价，2013/01-2013/12，已结题，主持。

3. 国家自然科学基金面上项目，30972101，牛卵母细胞冷冻前后CD9表达量对精卵结合的影响，2010/01-2012/12，已结题，主持。

   
   

专利情况

获得国家发明专利3项

社会兼职

中国畜牧兽医学会动物繁殖学分会理事