教师简介 姓名: | 于政权 |
| 性别: | 男 | 系别: | 生物化学与分子生物学 | 职称: | 教授 | 学位: | 博士 |
于政权 教授 博士生导师。
学习与工作经历 03/2009-2010/12 Research Associate 宾夕法尼亚大学 细胞发育和皮肤病系 2008-2009 助理研究科学家(Assistant Project Scientist) 加州大学, 尔湾分校 (Irvine) 生化和医学系 2004-2008. 博士后(Postdoctoral researcher), 加州大学, 尔湾分校(Irvine) 生化和医学系 09/2000-07/2003. Ph.D. 中国农业大学 生物学院 09/1997-07/2000. M.S. 生物学院, 河北师范大学 09/1993-07/1997. B.S. 生物学院, 河北师范大学
研究方向 我们实验室主要研究兴趣是利用转基因和基因敲除小鼠模拟疾病发生过程,揭示疾病发生机理,进行药物筛选。目前正在研究的课题包括:一方面,研究一些microRNA,RNA结合蛋白和转录因子在成体干细胞和疾病发生中的功能。另一方面,利用体内干细胞追踪技术细胞寻找干细胞的标记基因,探索干细胞在正常发育和癌症发生过程中的作用。
主讲课程 《高级生理和分子生物学》 《动物生物化学实验》
联系方式
电话:010-62734420 邮件:zyu at cau.edu.cn 通讯地址:生命科学中心3068
发表文章
Yue
Zhang1,7, Fengyin Li1,7, Yongli Song1, Xiaole
Sheng1, Kai Xiong2, Lei Chen3, Dequan Liu4,
Christopher Lengner5, Lixiang Xue2*, Zhengquan Yu1* Numb
and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial
identity, and support lactogenesis. The FASEB Journal DOI:10.1096/fj.201600387R Xianghui
Ma1¶, Yuhua Tian1¶, Yongli Song1, Jianyun Shi1,
Jiuzhi Xu1, Kai Xiong2, Jia Li1, Wenjie Xu1,
Yiqiang Zhao1, Jianwei Shuai3, Lei Chen4,
Maksim V. Plikus5,Christopher Lengner6, Fazheng
Ren1*, Lixiang Xue2* and Zhengquan Yu1* Msi2
maintains quiescent state of hair follicle stem cells by directly repressing
the Hh signaling pathway. Journal of Investigative Dermatology. Doi:10.1016/j.jid.2017.01.012 Ning
Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee
Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa
Rao, John Tobias, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan,
Sheila Shanka, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G.
Kharas, Brian D. Gregory, Zhengquan Yu* and
Christopher J. Lengner* The Msi family of RNA binding proteins
function redundantly as intestinal oncoproteins. Cell Reports. 2015
13(11):2440-55 (共同通讯作者,中国农业大学第一单位) Shukai Yuan,
Feifei Li, Qingyong Meng, Yiqiang Zhao, Lei Chen, Hongquan Zhang, Lixiang Xue,
Xiuqing Zhang, Christopher Lengner and Zhengquan Yu*,
Post-transcriptional regulation of keratinocyte progenitor cell expansion,
differentiation and hair follicle regression by miR-22. Plos Genetics.
2015 DOI:10.1371/journal pgen. 1005253. (月刊封面文章). (通讯作者) 注:受邀在在Plos blog发表文章亮点介绍内容: Zhengquan Yu. Understanding
images: microRNAs contribute to hair loss and follicle regression. Plos
Blog. 2015, june 15. http://blogs.plos.org/biologue/2015/06/16/understanding-images-micrornas-contribute-to-hair-loss-and-follicle-regression/ Shan Wang,
Maryam Yousefi8, Ning Li1, Angela Nakauka-Ddamba, Fan Li, Kimberly Parada1,
Shilpa Rao, Gerard Minuesa, Brian D. Gregory, Michael G. Kharas, Zhengquan
Yu* and Christopher J. Lengner* Transformation of the intestinal epithelium
by the MSI2 RNA binding protein. Nature Communications. 2015 doi:
10.1038/ncomms7517 (共同通讯作者, 中国农业大学第一单位) Jin
He, Qiuyan Li, Ying Guo, Tongxin Liu, Jianhua Ye, Zhengquan Yu, Ran Zhang,
Yaofeng Zhao, Xiaoxiang Hu, Changxin Wu, Xueyuan Bai, Xiangmei Chen, Ning Li,
PKD1 heterozygous knockout is sufficient to trigger renal cystogenesis in a
mini-pig ADPKD model, Int. J. Biol. Sci. 2015; 11(4): 361-369.
doi: 10.7150/ijbs.10858 Yarden Katz*, Feifei Li*, Nicole J. Lambert, Ethan M. Sokol ,Wai-Leong Tam,
Albert W. Cheng, Edoardo M. Airoldi, Christopher J. Lengner, Piyush B.
Gupta, Zhengquan Yu‡, Rudolf Jaenisch‡ and Christopher B.
Burge‡ Musashi Proteins are Post-transcriptional Regulatorsof the
Epithelial-Luminal Cell State. eLife. 2014 doi:
10.7554/eLife.03915. (共同通讯作者) 注:Science published
a short comment on this paper。 Lisa D. Chong,
Blocking tumor cell transition, Science. 16 January 2015. 347.6219.245-b:
[DOI:10.1126/science.347.6219.245-b] Salmans
ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen
B. The co-factor of LIM domains
(CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes
breast tumorigenesis. PLos Genetics. 2014
10(7):e1004520. doi: 10.1371 Yousefi M1,2, Li N1, Nakauka-Ddamba A1, Wang S, Davidow K1, Schoenberger J1, Yu Z3, Jensen
ST4, Kharas MG5, Lengner CJ.Msi RNA-binding proteins control
reserve intestinal stem cell quiescence. Journal of Cell
Biology. 2016 215(3):401-413. Jianhua
Ye, Jin He, Qiuyan Li , Yuanyuan Feng, Xueyuan Bai , Xiangmei
Chen, Yaofeng Zhao, Xiaoxiang Hu , Zhengquan Yu, Ning
Li. Generation of c-Myc transgenic pigs for
autosomal dominant polycystic kidney disease. Transgenic Res (2013)
22:1231–1239 Jin
He ,Jianhua Ye, Qiuyan Li, Yuanyuan
Feng,Xueyuan Bai,Xiangmei Chen, Changxin Wu, Zhengquan
Yu, Yaofeng
Zhao,Xiaoxiang Hu, Ning Li.
Construction of a transgenic pig model overexpressing polycystic kidney disease
2 (PKD2) gene. Transgenic Res (2013) 22:861–867 Suman
Verma, Michael L. Salmans, Mikhail Geyfman, Hong Wang, Zhengquan Yu,
Zhongxian Lu, Fang Zhao, Steven M. Lipkin, Bogi Andersen. The
estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and
facilitates lobuloalveolar development. Developmental Biology 2012
369(2): 249-60 A
Bhandari, W Gordon, D Dizon, AS Hopkin, E Gordon, Z Yu and B
Andersen. The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21
expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by
RNA-binding protein DND1. Oncogene (2012), 1–11 Zhengquan
Yu, J Mannik, A Soto, K Lin and B Andersen, The epidermal
differentiation associated Grainyhead gene Get1/Grhl3 also regulates urothelial
differentiation. The EMBO Journal 2009 28(13): 1890-903 Zhengquan
Yu, Ambica Bhandari, Jaana Mannik, Thu Pham, Xiaoman Xu, and Bogi Andersen,
Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading
edge during eyelid closure. Developmental Biology 2008 319(1):
56-67 N
Wang, K Lin, Z Lu, K Lam, R Newton, X Xu, Zhengquan Yu, G.
Gill, and Bogi Andersen. The LIM-only factor LMO4 regulates expression of the
BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation
and apoptosis of mammary epithelial cells. Oncogene, 2007
26(44):6431-41. X
Xu, J Mannik, E Kudryavtseva, K Lin, L Flanagan, J Spencer, A Soto, N Wang, Z
Lu, Zhengquan Yu, E Monuki and B Andersen, Co-factors of LIM
domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair
follicle stem cells. Developmental Biology 2007 312(2):484-500 Zhengquan
Yu, Kevin K. Lin, Ambica Bhandari, Joel A. Spencer, Xiaoman Xu, Ning Wang,
Zhongxian Lu, Gordon N. Gill, Dennis R. Roop, Philip Wertz and Bogi Andersen.
The Grainyhead-like Epithelial Transactivator Get-1/Grhl3 regulates epidermal
terminal differentiation and interacts functionally with LMO4. Developmental
Biology 2006 299(1):122-36 Zhengquan
Yu, Meng Qingyong, Yu Hongzhi, Fan Baoliang,Yu Shuyang, Fei Jing, Wang
Lili, Dai Yunping and Li Ning Expression and bioactivity of recombinant human
lysozyme in the milk of transgenic mice. J. Dairy Sci. 2006
89: 2911-2918 Zhengquan
Yu, Li Yan, Meng Qingyong, Zhao Zhihui, Li Wei, Yuan Jing, Hu Xiaoxiang,
Yan Bingxue, Fan Baoliang, Yu Shuyang and Li Ning. Comparative analysis of the
pig BAC sequence involved in the myostatin gene regulation. Science
in China C life sciences 2005 vol.48 No. 2 168-180. Sun
Ying*, Liu Delong*, Zhengquan Yu *, Zhang Qian, Bai Juan, Sun
Daye; An apoplastic mechanism for short term effects of rare earth elements at
lower concentrations. Plant Cell & Environment 2003
26(6):887-896 (*the authors contributed equally) Zhengquan
Yu, Fan Baoliang, Dai Yunping, Zheng Ming, Niu Huiling, Wang Meili, Wang
Lili, Fei Jing and Li Ning. Expression of recombinant human
lysozyme in the milk of transgenic mice. Chinese Science Bulletin 2003
48(21) 2331-2335 Zhengquan
Yu and Li ning, Animal cloning: the possible mechanisms and research
advancement. Letters in biotechnology. 2001 12 (4):
324-328 (In Chinese) Ma
Ligeng, Fan Qingshu, Zhengquan Yu, Zhou hualin, Zhang Fusuo and Sun
Daye, Does Aluminum inhibit pollen germination via extracellular
calmodulin? Plant Cell Physiology, 2000 41(3): 372-376 Meng
QY, Chen ZQ, Yu ZQ, Xie QF and Li N. Increased body weight via
injecting myogenic expression growth hormone-releasing hormone (GHRH) plasmid
DNA into sheep. Anim Biotechnol. 2004;15(2):175-92.
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