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于政权
发布日期：2018-09-14 浏览次数：　　信息来源：生物学院

教师简介

姓名：于政权            
性别：男
系别：生物化学与分子生物学
职称：教授
学位：博士











于政权 教授 博士生导师。


学习与工作经历

03/2009-2010/12 Research Associate 宾夕法尼亚大学 细胞发育和皮肤病系
2008-2009 助理研究科学家(Assistant Project Scientist) 加州大学, 尔湾分校 (Irvine) 生化和医学系
2004-2008. 博士后(Postdoctoral researcher), 加州大学, 尔湾分校(Irvine) 生化和医学系
09/2000-07/2003. Ph.D. 中国农业大学 生物学院 
09/1997-07/2000. M.S. 生物学院, 河北师范大学 
09/1993-07/1997. B.S. 生物学院, 河北师范大学


研究方向

我们实验室主要研究兴趣是利用转基因和基因敲除小鼠模拟疾病发生过程，揭示疾病发生机理，进行药物筛选。目前正在研究的课题包括：一方面，研究一些microRNA，RNA结合蛋白和转录因子在成体干细胞和疾病发生中的功能。另一方面，利用体内干细胞追踪技术细胞寻找干细胞的标记基因，探索干细胞在正常发育和癌症发生过程中的作用。


主讲课程

《高级生理和分子生物学》

《动物生物化学实验》


联系方式


电话：010-62734420
邮件：zyu at cau.edu.cn
通讯地址：生命科学中心3068


发表文章


  1. Yue Zhang1,7, Fengyin Li1,7, Yongli Song1, Xiaole Sheng1, Kai Xiong2, Lei Chen3, Dequan Liu4, Christopher Lengner5, Lixiang Xue2*, Zhengquan Yu1* Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis. The FASEB Journal DOI:10.1096/fj.201600387R

  2. Xianghui Ma1¶, Yuhua Tian1¶, Yongli Song1, Jianyun Shi1, Jiuzhi Xu1, Kai Xiong2, Jia Li1, Wenjie Xu1, Yiqiang Zhao1, Jianwei Shuai3, Lei Chen4, Maksim V. Plikus5，Christopher Lengner6, Fazheng Ren1*, Lixiang Xue2* and Zhengquan Yu1* Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway. Journal of Investigative Dermatology. Doi:10.1016/j.jid.2017.01.012

  3. Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa Rao, John Tobias, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan, Sheila Shanka, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G. Kharas, Brian D. Gregory, Zhengquan Yu* and Christopher J. Lengner* The Msi family of RNA binding proteins function redundantly as intestinal oncoproteins. Cell Reports. 2015 13(11):2440-55 （共同通讯作者，中国农业大学第一单位）

  4. Shukai Yuan, Feifei Li, Qingyong Meng, Yiqiang Zhao, Lei Chen, Hongquan Zhang, Lixiang Xue, Xiuqing Zhang, Christopher Lengner and Zhengquan Yu*, Post-transcriptional regulation of keratinocyte progenitor cell expansion, differentiation and hair follicle regression by miR-22. Plos Genetics. 2015 DOI:10.1371/journal pgen. 1005253. (月刊封面文章). (通讯作者)

    注：受邀在在Plos blog发表文章亮点介绍内容：

    Zhengquan Yu. Understanding images: microRNAs contribute to hair loss and follicle regression. Plos Blog. 2015, june 15.

    http://blogs.plos.org/biologue/2015/06/16/understanding-images-micrornas-contribute-to-hair-loss-and-follicle-regression/

  5. Shan Wang, Maryam Yousefi8, Ning Li1, Angela Nakauka-Ddamba, Fan Li, Kimberly Parada1, Shilpa Rao, Gerard Minuesa, Brian D. Gregory, Michael G. Kharas, Zhengquan Yu* and Christopher J. Lengner* Transformation of the intestinal epithelium by the MSI2 RNA binding protein. Nature Communications. 2015 doi: 10.1038/ncomms7517 (共同通讯作者, 中国农业大学第一单位)

  6. Jin He, Qiuyan Li, Ying Guo, Tongxin Liu, Jianhua Ye, Zhengquan Yu, Ran Zhang, Yaofeng Zhao, Xiaoxiang Hu, Changxin Wu, Xueyuan Bai, Xiangmei Chen, Ning Li, PKD1 heterozygous knockout is sufficient to trigger renal cystogenesis in a mini-pig ADPKD model, Int. J. Biol. Sci. 2015; 11(4): 361-369. doi: 10.7150/ijbs.10858 

  7. Yarden Katz*, Feifei Li*, Nicole J. Lambert, Ethan M. Sokol ,Wai-Leong Tam, Albert W. Cheng, Edoardo M. Airoldi, Christopher J. Lengner, Piyush B. Gupta, Zhengquan Yu‡, Rudolf Jaenisch‡ and Christopher B. Burge‡  Musashi Proteins are Post-transcriptional Regulatorsof the Epithelial-Luminal Cell State.  eLife. 2014 doi: 10.7554/eLife.03915. (共同通讯作者)

    注：Science published a short comment on this paper。

    Lisa D. Chong, Blocking tumor cell transition, Science. 16 January 2015. 347.6219.245-b: [DOI:10.1126/science.347.6219.245-b]

  8. Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B. The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis. PLos Genetics. 2014 10(7):e1004520. doi: 10.1371

  9. Yousefi M1,2, Li N1, Nakauka-Ddamba A1, Wang S, Davidow K1, Schoenberger J1, Yu Z3, Jensen ST4, Kharas MG5, Lengner CJ.Msi RNA-binding proteins control reserve intestinal stem cell quiescence. Journal of  Cell Biology. 2016 215(3):401-413.

  10. Jianhua Ye, Jin He,  Qiuyan Li ,  Yuanyuan Feng,  Xueyuan Bai , Xiangmei Chen, Yaofeng Zhao,  Xiaoxiang Hu ,  Zhengquan Yu, Ning Li.  Generation of c-Myc transgenic pigs for autosomal dominant polycystic kidney disease. Transgenic Res (2013) 22:1231–1239

  11. Jin He ，Jianhua Ye， Qiuyan Li，  Yuanyuan Feng，Xueyuan Bai，Xiangmei Chen，  Changxin Wu，  Zhengquan Yu，  Yaofeng Zhao，Xiaoxiang Hu，  Ning Li. Construction of a transgenic pig model overexpressing polycystic kidney disease 2 (PKD2) gene. Transgenic Res (2013) 22:861–867

  12. Suman Verma, Michael L. Salmans, Mikhail Geyfman, Hong Wang, Zhengquan Yu, Zhongxian Lu, Fang Zhao, Steven M. Lipkin, Bogi Andersen. The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development. Developmental Biology 2012 369(2): 249-60

  13. A Bhandari, W Gordon, D Dizon, AS Hopkin, E Gordon, Z Yu and B Andersen. The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. Oncogene (2012), 1–11

  14. Zhengquan Yu, J Mannik, A Soto, K Lin and B Andersen, The epidermal differentiation associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. The EMBO Journal 2009 28(13): 1890-903

  15. Zhengquan Yu, Ambica Bhandari, Jaana Mannik, Thu Pham, Xiaoman Xu, and Bogi Andersen, Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure. Developmental Biology 2008 319(1): 56-67

  16. N Wang, K Lin, Z Lu, K Lam, R Newton, X Xu,  Zhengquan Yu, G. Gill, and Bogi Andersen. The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells. Oncogene, 2007 26(44):6431-41.

  17. X Xu, J Mannik, E Kudryavtseva, K Lin, L Flanagan, J Spencer, A Soto, N Wang, Z Lu, Zhengquan Yu, E Monuki and B Andersen, Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Developmental Biology 2007 312(2):484-500

  18. Zhengquan Yu, Kevin K. Lin, Ambica Bhandari, Joel A. Spencer, Xiaoman Xu, Ning Wang, Zhongxian Lu, Gordon N. Gill, Dennis R. Roop, Philip Wertz and Bogi Andersen. The Grainyhead-like Epithelial Transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Developmental Biology 2006 299(1):122-36

  19. Zhengquan Yu, Meng Qingyong, Yu Hongzhi, Fan Baoliang,Yu Shuyang, Fei Jing, Wang Lili, Dai Yunping and Li Ning Expression and bioactivity of recombinant human lysozyme in the milk of transgenic mice. J. Dairy Sci. 2006 89: 2911-2918

  20. Zhengquan Yu, Li Yan, Meng Qingyong, Zhao Zhihui, Li Wei, Yuan Jing, Hu Xiaoxiang, Yan Bingxue, Fan Baoliang, Yu Shuyang and Li Ning. Comparative analysis of the pig BAC sequence involved in the myostatin gene regulation.  Science in China C life sciences 2005 vol.48 No. 2 168-180.

  21. Sun Ying*, Liu Delong*, Zhengquan Yu *, Zhang Qian, Bai Juan, Sun Daye; An apoplastic mechanism for short term effects of rare earth elements at lower concentrations. Plant Cell & Environment 2003 26(6):887-896 (*the authors contributed equally)

  22. Zhengquan Yu, Fan Baoliang, Dai Yunping, Zheng Ming, Niu Huiling, Wang Meili, Wang Lili, Fei Jing and  Li Ning.  Expression of recombinant human lysozyme in the milk of transgenic mice. Chinese Science Bulletin 2003 48(21) 2331-2335

  23. Zhengquan Yu and Li ning, Animal cloning: the possible mechanisms and research advancement.  Letters in biotechnology. 2001 12 (4): 324-328 (In Chinese)

  24. Ma Ligeng, Fan Qingshu, Zhengquan Yu, Zhou hualin, Zhang Fusuo and Sun Daye, Does Aluminum inhibit pollen germination via extracellular calmodulin? Plant Cell Physiology, 2000 41(3): 372-376

  25. Meng QY, Chen ZQ, Yu ZQ, Xie QF and Li N. Increased body weight via injecting myogenic expression growth hormone-releasing hormone (GHRH) plasmid DNA into sheep. Anim Biotechnol. 2004;15(2):175-92.


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