教师简介

姓名：	赵要风
性别：	男
系别：	生物化学与分子生物学
职称：	教授
学位：	博士

赵要风 教授，1970年生，博士，教授，博士生导师，国家杰出青年基金获得者。主要研究领域为动物分子免疫遗传学。在过去10余年的时间内，其课题组围绕动物适应性免疫系统的关键基因例如：免疫球蛋白（B细胞受体）基因， T细胞受体基因，MHC等开展了一系列物种间的比较研究工作。发表论文90余篇，被引2000余次。

学习与工作经历

2006年3月至现在: 中国农业大学生物学院, 校特聘教授
1998年8月至2006年3月: Karolinska Institute, Stockholm, Sweden, postdoctoral fellow
1995年9月至1998年6月:中国农业大学动物科技学院动物遗传育种专业, 获博士学位
1992年9月至1995年6月: 中国农业大学生物学院动物生理生化专业, 获硕士学位
1988年9月至1992年6月: 河南大学生物系生物学专业,获学士学位

研究方向

在前期工作的基础上，目前课题组的主要研究方向包括：

1. 脊椎动物免疫基因的比较和进化研究

2. 免疫球蛋白（抗体）转运机制研究

3. 非驼科动物来源重链抗体（纳米抗体）生产平台的建立与应用

4. 家养动物病毒抗性相关基因的高通量筛选

主讲课程

《动物科学Seminar》(研究生)

联系方式

电话：010-62734945
邮件：yaofengzhao at cau.edu.cn
通讯地址：北京市圆明园西路2号中国农业大学农业生物技术国家重点实验，100193

发表文章

* Corresponding author

2020

Revisiting the Pig IGHC Gene Locus in Different Breeds Uncovers Nine Distinct IGHG Genes. Zhang M, Li Z, Li J, Huang T, Peng G, Tang W, Yi G, Zhang L, Song Y, Liu T, Hu X, Ren L, Liu H, Butler JE, Han H*, Zhao Y*. J Immunol. 2020 Oct 15; 205(8):2137-2145

Analysis of the Chinese Alligator TCRα/δ Loci Reveals the Evolutionary Pattern of Atypical TCRδ/TCRμ in Tetrapods. Wang X, Huang J, Wang P, Wang R, Wang C, Yu D, Ke C, Huang T, Song Y, Bai J, Li K, Ren L, Miller RD, Han H*, Zhou X*, Zhao Y*. J Immunol. 2020 Aug 1; 205(3):637-647

Genetic removal of the CH1 exon leads to the production of hypofunctional heavy chain-only IgG2a in rats. Li Z, Zhang M, Zheng S, Song Y, Cheng X, Yu D, Du L, Ren L, Han H*, Zhao Y*. Transgenic Res. 2020 Apr;29(2):199-213

The Immunoglobulins: New Insights, Implications, and Applications. Sun Y, Huang T, Hammarström L, Zhao Y*. Annu Rev Anim Biosci. 2020 Feb 15;8:145-169.

2019

Generation of porcine monoclonal antibodies based on single cell technologies. Li K, Bai J, Du L, Wang X, Ke C, Yan W, Li C, Ren L, Han H*, Zhao Y*. Vet Immunol Immunopathol. 2019 Sep;215:109913.

A high-throughput screen for genes essential for PRRSV infection using a piggyBac-based system.Bai J, Li K, Tang W, Liang Z, Wang X, Feng W, Zhang S, Ren L, Wu S*, Han H*, Zhao Y*. Virology. 2019 May;531:19-30.

Identification of Two Nonrearranging IgSF Genes in Chicken Reveals a Novel Family of Putative Remnants of an Antigen Receptor Precursor.Fu Y, Yang Z, Huang J, Cheng X, Wang X, Yang S, Ren L, Lian Z, Han H*, Zhao Y*. J Immunol. 2019 Apr 1;202(7):1992-2004.

2018

Identification of a Transcriptionally Forward α Gene and Two υ Genes within the Pigeon (Columba livia) IgH Gene Locus. Huang T, Wang X, Si R, Chi H, Han B, Han H, Cao G*, Zhao Y*. J Immunol. 2018 Jun 1;200(11):3720-3728.

Truncation of the Murine Neonatal Fc Receptor Cytoplasmic Tail Does Not Alter IgG Metabolism or Transport In Vivo. Ma Y, Ke C, Wan Z, Li Z, Cheng X, Wang X, Zhao J, Ma Y, Ren L, Han H*, Zhao Y*. J Immunol. 2018 Feb 15;200(4):1413-1424.

 Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy. Zou Y, Dong Y, Meng Q, Zhao Y*, Li N*. Sci Rep. 2018 Feb 9;8(1):2781. 

2017

Convergent and divergent genetic changes in the genome of Chinese and European pigs. Wang J, Zou H, Chen L, Long X, Lan J, Liu W, Ma L, Wang C, Xu X, Ren L, Gu Z, Li N, Hu X, Zhao Y*, Zhao Y*. Sci Rep. 2017 Aug 17;7(1):8662

A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck. Yang Z, Sun Y, Ma Y, Li Z, Zhao Y, Ren L, Han H, Jiang Y*, Zhao Y*. Sci Rep. 2017 Jan 30;7:41426.

2016

Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds. Han B, Yuan H, Wang T, Li B, Ma L, Yu S, Huang T, Li Y, Fang D, Chen X, Wang Y, Qiu S, Guo Y, Fei J, Ren L, Pan-Hammarström Q, Hammarström L, Wang J, Wang J, Hou Y, Pan Q*, Xu X*, Zhao Y*. J Immunol. 2016 Jun 15;196(12):5138-47

Internal Duplications of DH, JH, and C Region Genes Create an Unusual IgH Gene Locus in Cattle. Ma L, Qin T, Chu D, Cheng X, Wang J, Wang X, Wang P, Han H, Ren L, Aitken R, Hammarström L, Li N, Zhao Y*. J Immunol. 2016 May 15;196(10):4358-66.

2014

Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish. Zhang T, Tacchi L, Wei Z, Zhao Y*, Salinas I*. Immunogenetics. 2014 May;66(5):335-51.

2013

Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians.　Cheng G, Gao Y, Wang T, Sun Y, Wei Z, Li L, Ren L, Guo Y, Hu X, Lu Y, Wang X, Liu G, Zhang C, Yu J, Pan-Hammarström Q, Hammarström L, Wu X, Li N, Zhao Y*. Nat Commun. 2013;4:1337.　

A comparative overview of immunoglobulin genes and the generation of their diversity in tetrapods. Sun Y, Wei Z, Li N, Zhao Y*. Dev Comp Immunol. 2013 Jan;39(1-2):103-9. (*corresponding author)

2012

Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates. Sun Y, Liu Z, Li Z, Lian Z, Zhao Y*. Front Immunol. 2012 Dec 20;3:392.

Expressional analysis of immunoglobulin D in cattle (Bos taurus), a large domesticated ungulate. Xu B, Wang J, Zhang M, Wang P, Wei Z, Sun Y, Tao Q, Ren L, Hu X, Guo Y, Fei J, Zhang L, Li N, Zhao Y*. PLoS One. 2012;7(9):e44719.

Extensive diversification of IgD-, IgY-, and truncated IgY(δFc)-encoding genes in the red-eared turtle (Trachemys scripta elegans). Li L, Wang T, Sun Y, Cheng G, Yang H, Wei Z, Wang P, Hu X, Ren L, Meng Q, Zhang R, Guo Y, Hammarström L, Li N, Zhao Y. J Immunol. 2012 Oct 15;189(8):3995-4004.

Immunoglobulin genes and diversity: what we have learned from domestic animals. Sun Y, Liu Z, Ren L, Wei Z, Wang P, Li N, Zhao Y. J Anim Sci Biotechnol. 2012 Jun 20;3(1):18.

Evidence of IgY subclass diversification in snakes: evolutionary implications. Wang T, Sun Y, Shao W, Cheng G, Li L, Cao Z, Yang Z, Zou H, Zhang W, Han B, Hu Y, Ren L, Hu X, Guo Y, Fei J, Hammarström L, Li N, Zhao Y*. J Immunol. 2012 Oct 1;189(7):3557-65.

Immunoglobulin genomics in the guinea pig (Cavia porcellus). Guo Y, Bao Y, Meng Q, Hu X, Meng Q, Ren L, Li N, Zhao Y*. PLoS One. 2012;7(6):e39298.

Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian species. Huang T, Zhang M, Wei Z, Wang P, Sun Y, Hu X, Ren L, Meng Q, Zhang R, Guo Y, Hammarstrom L, Li N, Zhao Y*. PLoS One. 2012;7(3):e34346.

2011

Characterization of the MHC class II α-chain gene in ducks. Ren L, Yang Z, Wang T, Sun Y, Guo Y, Zhang Z, Fei J, Bao Y, Qin T, Wang J, Huang Y, Hu X, Zhao Y*, Li N*. Immunogenetics. 2011 Oct;63(10):667-78.

A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana). Guo Y, Bao Y, Wang H, Hu X, Zhao Z, Li N, Zhao Y*. PLoS One. 2011 Feb 25;6(2):e16889.

The immunoglobulin δ gene in jawed vertebrates: a comparative overview. Sun Y, Wei Z, Hammarstrom L, Zhao Y. Dev Comp Immunol. 2011 Sep;35(9):975-81.

2010

A comprehensive analysis of germline and expressed immunoglobulin repertoire in the horse. Sun Y, Wang C, Wang Y, Zhang T, Ren L, Hu X, Zhang R, Meng Q, Guo Y, Fei J, Li N, Zhao Y*. Dev Comp Immunol. 2010 Sep;34(9):1009-1020.

Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis. Wu Q, Wei Z, Yang Z, Wang T, Ren L, Hu X, Meng Q, Guo Y, Zhu Q, Robert J, Hammarstrom L, Li N*, Zhao Y*. Dev Comp Immunol. 2010 May; 34(5):579-89.

The immunoglobulin gene loci in the teleost Gasterosteus aculeatus. Bao Y*, Wang T, Guo Y, Zhao Z, Li N, Zhao Y*. Fish Shellfish Immunol. 2010 Jan;28(1):40-8.

2009

Expression of IgM, IgD, and IgY in a reptile, Anolis carolinensis. Wei Z, Wu Q, Ren L, Hu X, Guo Y, Warr GW, Hammarström L, Li N, Zhao Y*. J Immunol. 2009 Sep 15;183(6):3858-64.

Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods. Zhao Y*#, Cui H#, Whittington CM, Wei Z, Zhang X, Zhang Z, Yu L, Ren L, Hu X, Zhang Y, Hellman L, Belov K, Li N, Hammarström L*. J Immunol. 2009 Sep 1;183(5):3285-93.

2008

Genomic organization of the immunoglobulin light chain gene loci in Xenopus tropicalis: evolutionary implications. Qin T, Ren L, Hu X, Guo Y, Fei J, Zhu Q, Butler JE, Wu C, Li N, Hammarstrom L, Zhao Y*. Dev Comp Immunol. 2008;32(2):156-65.

2007

Physical mapping of the giant panda immunoglobulin heavy chain constant region genes. Zhao Z#, Zhao Y#, Pan-Hammarström Q, Liu W, Liu Z, Zhao Y, Li N, Hammarström L. Dev Comp Immunol. 2007;31(10):1034-49.

 2006

Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis. Zhao Y*, Pan-Hammarström Q, Yu S, Wertz N, Zhang X, Li N, Butler JE, Hammarström L*. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12087-92.

The bovine antibody repertoire. Zhao Y, Jackson SM, Aitken R. Dev Comp Immunol. 2006;30(1-2):175-86.

 2005

Selective IgG2 deficiency due to a point mutation causing abnormal splicing of the Cg2 gene. Zhao Y*, Pan-Hammarström Q, Zhao Z, Wen S, Hammarström L. Int Immunol. 2005 Jan;17(1):95-101.

Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis. Zhao Y*, Pan-Hammarström Q, Zhao Z, Hammarström L. Dev Comp Immunol. 2005;29(1):61-71.

2003

Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn alpha chain. Zhao Y, Kacskovics I, Zhao Z, Hammarström L. Vet Immunol Immunopathol. 2003 Dec 15;96(3-4):229-33.

The porcine Ig delta gene: unique chimeric splicing of the first constant region domain in its heavy chain transcripts. Zhao Y*, Pan-Hammarström Q, Kacskovics I, Hammarström L. J Immunol. 2003 Aug 1;171(3):1312-8.

Physical mapping of the bovine immunoglobulin heavy chain constant region gene locus. Zhao Y, Kacskovics I, Rabbani H, Hammarstrom L. J Biol Chem. 2003 Sep 12;278(37):35024-32.

Cloning of the complete rat immunoglobulin delta gene: evolutionary implications. Zhao Y, Hammarström L. Immunology. 2003 Mar;108(3):288-95.

2002

Artiodactyl IgD: the missing link. Zhao Y*, Kacskovics I, Pan Q, Liberles DA, Geli J, Davis SK, Rabbani H, Hammarstrom L. J Immunol. 2002 Oct 15;169(8):4408-16.

 2000

Mapping of the chicken immunoglobulin heavy-chain constant region gene locus reveals an inverted alpha gene upstream of a condensed upsilon gene. Zhao Y, Rabbani H, Shimizu A, Hammarström L. Immunology. 2000 Nov;101(3):348-53.

获奖情况

2002年度教育部自然科学一等奖

2003年度国家技术发明二等奖

承担项目及课题

1. 中国农业大学人才引进项目(2006-2008)

2. 863高科技计划(2006-2010)

3. 自然科学基金(2007-2009)

4. 教育部新世纪优秀人才支持计划(2007-2010)

5. 国家杰出青年基金(2008-2011)

专利情况

现有美国专利一项 

社会兼职

暂无