教师简介

姓名：	张然
性别：	女
系别：	生物化学与分子生物学
职称：	副教授
学位：	博士

学习与工作经历

1999.09-2003.07 沈阳农业大学 生物技术专业 理学学士学位

2003.09-2009.06 中国农业大学 生化与分子生物学专业 理学博士学位

2007.09-2008.09 瑞典卡罗林斯卡医学院临床免疫系 博士联合培养

2009.07-至今 中国农业大学 生物学院 讲师，副教授

研究方向

基因修饰疾病动物模型制备及其分子机制研究

主讲课程

《基因工程概论》（本科生）

联系方式

电话：62731327

邮箱：zhangran0628 at cau.edu.cn

发表文章

1. Han Q, Chen H, Wang L, An Y, Hu X, Zhao Y, Zhang H, Zhang R*. Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling. Int J Biol Sci. 2021 Oct 3;17(15):4108-4121. 

2. Xue Z, Han Q, Huang P, Jiang X, Tan M, Zhao Y, Li N, Zhang R*. Characterization of Functional Components in Bovine Colostrum That Inhibit Norovirus Capsid Protruding Domains Interacting with HBGA Ligands. Pathogens. 2021 Jul 7;10(7):857.

3. Zhang R, Tang C, Guo H, Tang B, Chen Z, Dai Y, Li N. A novel glycosylated anti-CD20 monoclonal antibody from transgenic cattle. Sci Rep. 2018 Sep 4;8(1):13208.

4. Zheng Y, Song Y, Han Q, Liu W, Xu J, Yu Z, Zhang R*, Li N. IEC-specific IGF1 promotes the expansion of intestinal stem cells during epithelial regeneration and functions on the intestinal immune homeostasis. Am J Physiol Endocrinol Metab, 2018 Oct 1;315(4):E638-E649.

5. Cui D, Li F, Li Q, Li J, Zhao Y, Hu X, Zhang R*, Li N*. Generation of a iniature pig disease model for human Laron syndrome. Sci Rep. 2015 Oct 29;5:15603.

6. Cui D, Zhang L, Li J, Zhao Y, Hu X, Dai Y, Zhang R*, Li N*. Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice. PLoS One. 2014 Dec 29;9(12):e115972.

7. Günaydın G, Zhang R, Hammarström L, Marcotte H. Engineered Lactobacillus rhamnosus GG expressing IgG-binding domains of protein G: Capture of hyperimmune bovine colostrum antibodies and protection against diarrhea in a mouse pup rotavirus infection model. Vaccine. 2014 Jan 16;32(4):470-7.

8. Zhang R, Yin Y, Zhang Y, Li K, Zhu H, Gong Q, Wang J, Hu X, Li N. Molecular characterization of transgene integration by next-generation sequencing in transgenic cattle. PLoS One. 2012;7(11):e50348.

9. Zhang R, Guo C, Sui S, Yu T, Wang J, Li N. Comprehensive assessment of milk composition in transgenic cloned cattle. PLoS One. 2012;7(11):e49697.

10. Zhang R, Cui D, Wang H, Li C, Yao X, Zhao Y, Liang M, Li N. Functional recombinant human anti-HBV antibody expressed in milk of transgenic mice. Transgenic Res. 2012 Oct;21(5):1085-91.

11. Zhang R, Zhao Z, Zhao Y, Kacskovics I, Eijk Mv, Groot Nd, Li N, Hammarstrom L. Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum. Anim Biotechnol. 2009;20(4):242-6.

12. Zhang R, Rao M, Li C, Cao J, Meng Q, Zheng M, Wang M, Dai Y, Liang M, Li N. Functional recombinant human anti-HAV antibody expressed in milk of transgenic mice. Transgenic Res. 2009 Jun;18(3):445-53. 

获奖情况

承担项目及课题

专利情况

猪小肠上皮细胞表达的PGC启动子及其应用

猪特异性友好位点Pifs501及其应用

社会兼职