教师简介

姓名：	赵毅强
性别：	男
系别：	生物化学与分子生物学
职称：	副教授
学位：	博士

学习与工作经历

　　赵毅强 毕业于中国农业大学，后在美国印第安纳大学医学院和巴克衰老研究所从事博士后工作。

研究方向

　　课题组以农业动物为主要研究对象，从事基于下一代测序等高通量方法的动物基因组分析，研究动物驯化过程中的重要事件，包括早期自然选择、人工选择和基因交流等。同时本课题组也开发基于下一代测序的检测和分析方法，用于转基因动植物的鉴定，动物祖源分析和基因组评价。

主讲课程

本科生课程《生物信息学》
本科生课程 《SAS数据操作和统计分析》

联系方式

电话：010-62733104
邮件：yiqiangz at cau.edu.cn
通讯地址：中国农业大学西校区神内楼

发表文章

1. Liu Q，Iqbal M F，Yaqub T，Firyal S，Zhao Y，Stoneking M，Li M (2022). "The transmission of human mitochondrial DNA in four-generation pedigrees." Human Mutation, : 1-9.

2. Wang Y，Zhang C，Peng Y，Cai X，Hu X，Bosse M，Zhao Y (2022). "Whole-genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration." Evolutionary Applications, 15(3): 501–514.

3. Peng Y，Cai X，Wang Y，Liu Z，Zhao Y (2022). "Genome-wide analysis suggests multiple domestication events of Chinese local pigs." Animal Genetics, 53(3): 293–306.

4. Yang R，Xu Z，Wang Q，Zhu D，Bian C，Ren J，Huang Z，Zhu X，Tian Z，Wang Y，Jiang Z，Zhao Y，Zhang D，Li N，Hu X (2021). "Genome‑wide association study and genomic prediction for growth traits in yellow-plumage chicken using genotyping-by-sequencing." Genetics, selection, evolution, 53(1): 1-15.

5. Yang R， Guo X， Zhu D， Tan C， Bian C， Ren J， Huang Z， Zhao Y， Cai G， Liu D， Wu Z， Wang Y， Li N， Hu X (2021). "Accelerated deciphering of the genetic architecture of agricultural economic traits in pigs using a low-coverage whole-genome sequencing strategy." Gigascience, 10(7):1-14.

6. Wu J，Liu Y，Zhao Y (2021). "Systematic Review on Local Ancestor Inference From a Mathematical and Algorithmic Perspective." Frontiers in Genetics, 12: 1-11.

7. Wu J，Lin D，Jiu L，Liu Q，Gu Z，Luo J，Zhao Y (2021). "Exploring epigenetic biomarkers of universal specificities and commonalities among pan-cancer cohorts in The Cancer Genome Atlas." Epigenomics, 13(8): 599-612.

8. Wang Y，Liu Y，Zhao Y，Luo J (2020). "Quantification of circadian rhythm in mitochondrial DNA copy number in whole blood, and identification of factors that influence it." Cellular and Molecular Biology, 66(5): 179-184.

9. Wang Y，Cao X，Luo C，Sheng Z，Zhang C，Bian C，Feng C，Li J，Gao F，Zhao Y，Jiang Z，Qu H，Shu D，Carlborg Ö，Hu X，Li N (2020). "Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits." Communications Biology, 3(1): 1-13.

10. Wang Y，Bu L，Cao X，Qu H，Zhang C，Huang Z，Ren J，Zhao Y，Luo C，Hu X，Shu D，Li N (2020). "Genetic Dissection of Growth Traits in a Unique Chicken Advanced Intercross Line." Frontiers in Genetics, 11: 1-11.

11. Song Y，Guerrero-Juarez CF，Chen Z，Tang Y，Ma X，Lv C，Bi X，Deng M，Bu L，Tian Y，Liu R，Zhao R，Xu J，Sheng X，Du S，Liu Y，Zhu Y，Shan S-J，Chen H-D，Zhao Y，Zhou G，Shuai J，Ren F，Xue L，Ying Z，Dai X，Lengner CJ，Andersen B，Plikus MV，Nie Q，Yu Z (2020). "The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease." Cell research, 30(10): 854-872.

12. Lin D，Wang R，Luo J，Ren F，Gu Z，Zhao Y，Zhao L (2020). "The Core and Distinction of the Gut Microbiota in Chinese Populations across Geography and Ethnicity." Microorganisms, 8(10): 1-14

13. Bu L，Wang Q，Gu W，Yang R，Zhu D，Song Z，Liu X，Zhao Y (2020). "Improving read alignment through the generation of alternative reference via iterative strategy." Scientifc Reports, 10(1): 1-11.

14. Zhang C，Lin D，Wang Y，Peng D，Li H，Fei J，Chen K，Yang N，Hu X，Zhao Y，Li N (2019). "Widespread introgression in Chinese indigenous chicken breeds from commercial broiler." Evolutionary Applications, 12(3): 610-621.

15. Xu W，Li S，Zhang Z，Hu J，Zhao Y (2019). "Prioritization of differentially expressed genes through integrating public expression data." Animal Genetics, 50(6): 726-732.

16. Wu J，Zhao Y (2019). "Machine learning technology in the application of genome analysis: A systematic review." Gene, 705: 149-156.

17. Liu Q，Lin D，Li M，Gu Z，Zhao Y (2019). "Evidence of Neutral Evolution of Mitochondrial DNA in Human Hepatocellular Carcinoma." Genome Biology and Evolution, 11(10): 2909-2916.

18. Liang Z，Bu L，Qin Y，Peng Y，Yang R，Zhao Y (2019). "Selection of Optimal Ancestry Informative Markers for Classification and Ancestry Proportion Estimation in Pigs." Frontiers in Genetics, 10: 1-13.

19. Li J，Hu Y，Li L，Wang Y，Li Q，Gu X，Zhao Y，Lan H，Larsson M，Feng C，Hu X，Li N (2019). "A Discovery of a Genetic Mutation Causing Reduction of Atrogin-1 Expression in Broiler Chicken Muscle." Frontiers in Genetics, 10: 1-12.

20. Fu W，Wang C，Xu W，Zhu P，Lu Y，Wei S，Wu X，Wu Y，Zhao Y，Zhu S (2019). "Unintended effects of transgenic rice revealed by transcriptome and metabolism." GM Crops & Food-Biotechnology in Agriculture and the Food Chain, 10(1): 20-34.

21. An J，Li J，Wang Y，Wang J，Li Q，Zhou H，Hu X，Zhao Y，Li N (2019). "A Homeostasis Hypothesis of Avian Influenza Resistance in Chickens." Genes, 10(7): 1-16.

22. Yu D，Wang J，Zou H，Feng T，Chen L，Li J，Qi X，Li Z，Duan X，Xu C，Zhang L，Long X，Lan J，Chen C，Wang C，Xu X，Ren J，Zhao Y，Hu X，Lian Z，Men H，Pan D，Li N，Capecchi M R，Du X，Zhao Y，Wu S (2018). "Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning." Proc Natl Acad Sci U S A., 115(47): E11071-E11080.

23. Pan Z，Li S，Liu Q，Wang Z，Zhou Z，Di R，Miao B，Hu W，Wang X，Hu X，Xu Z，Wei D，He X，Yuan L，Guo X，Liang B，Wang R，Li X，Cao X，Dong X，Xia Q，Shi H，Hao G，Yang J，Luosang C，Zhao Y，Jin M，Zhang Y，Lv S，Li F，Ding G，Chu M，Li Y (2018). "Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization." GigaScience, 7(4): 1-15.

24. Ma L，Wang Y，Wang H，Hu Y，Chen J，Tan T，Hu M，Liu X，Zhang R，Xing Y，Zhao Y，Hu X，Li N (2018). "Screen and Verification for Transgene Integration Sites in Pigs." Scientific Reports, 8(1): 1-11.

25. Yue S，Zhao Y，Gu X，Yin B，Jiang Y，Wang Z，Shi K (2017). "A genome-wide association study suggests new candidate genes for milk production traits in Chinese Holstein cattle." Animal Genetics, 48(6): 677-681.

26. Yang R，Fang S，Wang J，Zhang C，Zhang R，Liu D，Zhao Y，Hu X，Li N (2017). "Genome-wide analysis of structural variants reveals genetic differences in Chinese pigs." PLoS ONE, 12(10): 1-18.

27. Wang Y，Li J，Feng C，Zhao Y，Hu X，Li N (2017). "Transcriptome analysis of comb and testis from Rose-comb Silky chicken (R1/R1) and Beijing Fatty wild type chicken (r/r)." Poultry Science, 96(6): 1866-1873.

28. Wang Y，Cao X，Zhao Y，Fei J，Hu X，Li N (2017). "Optimized double-digest genotyping by sequencing (ddGBS) method with highdensity SNP markers and high genotyping accuracy for chickens." PLoS ONE, 12(6): 1-19.

29. Wang Q，Shi N，Shang Y，Liu X，Fu W，Zhao Y，Pan D，Xu W，Lin X (2017). "Comprehensive molecular characterization of a transgenic pig expressing hCD46 gene." Gene, 626: 367-385.

30. Wang J，Zou H，Chen L，Long X，Lan J，Liu W，Ma L，Wang C，Xu X，Ren L，Gu Z，Li N，Hu X，Zhao Y，Zhao Y (2017). "Convergent and divergent genetic changes in the genome of Chinese and European pigs." Scientific Reports, 7(1): 1-13.

31. Ma X，Tian Y，Song Y，Shi J，Xu J，Xiong K，Li J，Xu W，Zhao Y，Shuai J，Chen L，Plikus M V，Lengner C J，Ren F，Xue L，Yu Z (2017). "Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway." Journal of Investigative Dermatology, 137(5): 1015-1024.

32. Liu L，Yan X，Kong X，Zhao Y，Gong Z，Jin J B，Guo Y (2017). "Transcriptional Gene Silencing Maintained by OTS1 SUMO Protease Requires a DNA-Dependent Polymerase V-Dependent Pathway." Plant Physiology, 173(1): 655-667.

33. Kou H，Zhao Y，Ren K，Chen X，Lu Y，Wang D (2017). "Automated measurement of cattle surface temperature and its correlation with rectal temperature." PLoS ONE, 12(4): 1-10.

34. Guo Y，Gu X，Sheng Z，Wang Y，Luo C，Liu R，Qu H，Shu D，Wen J，Crooijmans R P M A，Carlborg Ö，Zhao Y，Hu X，Li N (2016). "A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens." PLoS Genetics, 12(6): 1-24.

35. Chen L，Guo W，Ren L，Yang M，Zhao Y，Guo Z，Yi H，Li M，Hu Y，Long X，Sun B，Li J，Zhai S，Zhang T，Tian S，Meng Q，Yu N，Zhu D，Tang G，Tang Q，Ren L，Liu K，Zhang S，Che T，Yu Z，Wu N，Jing L，Zhang R，Cong T，Chen S，Zhao Y，Zhang Y，Bai X，Guo Y，Zhao L，Zhang F，Zhao H，Zhang L，Hou Z，Zhao J，Li J，Zhang L，Sun W，Zou X，Wang T，Ge L，Liu Z，Hu X，Wang J，Yang S，Li N (2016). "A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs." BMC Biology, 14: 1-15.

36. Yuan S，Li F，Meng Q，Zhao Y，Chen L，Zhang H，Xue L，Zhang X，Lengner C，Yu Z (2015). "Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22." PLoS Genetics, 11(5): 1-23.

37. Li J，Li R，Wang Y，Hu X，Zhao Y，Li L，Feng C，Gu X，Liang F，Lamont S J，Hu S，Zhou H，Li N (2015). "Genome-wide DNA methylome variation in two genetically distinct chicken lines using MethylC-seq." BMC Genomics, 16: 1-13.

38. Momcilovic´ O，Liu Q，Swistowski A，Russo-Tait T，Zhao Y，Rao M S，Zeng X (2014). "Genome Wide Profiling of Dopaminergic Neurons Derived from Human Embryonic and Induced Pluripotent Stem Cells." Stem Cells And Development, 23(4): 406-420.

39. Katzman SM，Strotmeyer ES，Nalls MA，Zhao Y，Mooney S，Schork N，Harris TB，Yaffe K，Cummings SR，Liu Y，Newman AB，Tranah GJ，Health A, And Body Composition Study (2014). "Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly." Journals of Gerontology, 70(11): 1400-1408.

40. Feng C，Gao Y，Dorshorst B，Song C，Gu X，Li Q，Li J，Liu T，Rubin C-J，Zhao Y，Wang Y，Fei J，Li H，Chen K，Qu H，Shu D，Ashwell C，Da Y，Andersson L，Hu X，Li N (2014). "A cis-Regulatory Mutation of PDSS2Causes Silky-Feather in Chickens." PLoS Genetics, 10(8): 1-16.

41. Huang Y，Li Y，Burt DW，Chen H，Zhang Y，Qian W，Kim H，Gan S，Zhao Y，Li J，Yi K，Feng H，Zhu P，Li B，Liu Q，Fairley S，Magor KE，Du Z，Hu X，Goodman L，Tafer H，Vignal A，Lee T，Kim K-W，Sheng Z，An Y，Searle S，Herrero J，Groenen M a M，Crooijmans R P M A，Faraut T，Cai Q，Webster RG，Aldridge JR，Warren WC，Bartschat S，Kehr S，Marz M，Stadler PF，Smith J，Kraus R H S，Zhao Y，Ren L，Fei J，Morisson M，Kaiser P，Griffin DK，Rao M，Pitel F，Wang J，Li N (2013). "The duck genome and transcriptome provide insight into an avian influenza virus reservoir species." Nature Genetics, 45(7): 776-783.

42. Zhao Y，Mooney SD (2012). "Functional organization and its implication in evolution of the human protein-protein interaction network." BMC Genomics, 13: 1-10.

43. Tranah GJ，Nalls MA，Katzman SM，Yokoyama JS，Lam ET，Zhao Y，Mooney S，Thomas F，Newman AB，Liu Y，Cummings SR，Harris TB，Yaffe K (2012). "Mitochondrial DNA Sequence Variation Associated with Dementia and Cognitive Function in the Elderly." Journal of Alzheimer’s Disease, 32(2): 357-372.

44. Tranah GJ，Lam ET，Katzman SM，Nalls MA，Zhao Y，Evans DS，Yokoyama JS，Pawlikowska L，Kwok P-Y，Mooney S，Kritchevsky S，Goodpaster BH，Newman A B，Harris T B，Manini T M，Cummings S R (2012). "Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly." Biochimica et Biophysica Acta, 1817(9): 1691-1700.

45. Liu Q，Zhang J，Guo W，Zhao Y，Hu X，Li N (2012). "Identifying lipid metabolism genes in pig liver after clenbuterol administration." Frontiers in Bioscience, 4: 2605-2616.

46. Zhao Y，Clark W，Mort M，Cooper DN，Radivojac P，Mooney SD (2011). "Prediction of Functional Regulatory SNPs in Monogenic and Complex Disease." Human Mutation, 32(10): 1183-1190.

47. Liu Q，Gu X，Zhao Y，Zhang J，Zhao Y，Meng Q，Xu G，Hu X，Li N (2010). "Pig large tumor suppressor 2 (Lats2), a novel gene that may regulate the fat reduction in adipocyte." BMB Reports, 43(2): 97-102.

48. He Z，Zhao Y，Mei G，Li N，Chen Y (2010). "Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?" Transgenic Research, 19(4): 519-533.

49. Sadat MA，Dirscherl S，Sastry L，Dantzer J，Pech N，Griffin S，Hawkins T，Zhao Y，Barese CN，Cross S，Orazi A，An C，Goebel WS，Yoder MC，Li X，Grez M，Cornetta K，Mooney SD，Dinauer MC (2009). "Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation." Gene Therapy, 16(12): 1452-1464.

50. Jung J，Zhao Y (2009). "Allelic Based Gene-Gene Interaction in Case-Control Studies." Human Heredity, 69(1): 14-27.

51. Du Z，Zhao Y，Li N (2009). "Genome-wide colonization of gene regulatory elements by G4 DNA motifs." Nucleic Acids Research, 37(20): 6784-6798.

52. Liu Y，Wu Q，Cui H，Li Q，Zhao Y，Luo J，Liu Q，Sun X，Tang B，Zhang L，Dai Y，Li N (2008). "Expression of EGFP and NPTII Protein Is Not Associated with Organ Abnormalities in Deceased Transgenic Cloned Cattle." Cloning Stem Cells, 10(4): 421-428.

53. Du Z，Zhao Y，Li N (2008). "Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription." Genome Research, 18(2): 233-241.

54. Zhao Y，Du Z，Li N (2007). "Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals." FEBS Letter, 581(10): 1951-1956.

55. Lu W，Zhao Z，Zhao Y，Yu S，Zhao Y，Fan B，Kacskovics I，Hammarstro¨M L，Li N (2007). "Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice." Immunology, 122(3): 401-408.

56. Wong G K-S，Liu B，Wang J，Zhang Y，Yang X，Zhang Z，Meng Q，Zhou J，Li D，Zhang J，Ni P，Li S，Ran L，Li H，Zhang J，Li R，Li S，Zheng H，Lin W，Li G，Wang X，Zhao W，Li J，Ye C，Dai M，Ruan J，Zhou Y，Li Y，He X，Zhang Y，Wang J，Huang X，Tong W，Chen J，Ye J，Chen C，Wei N，Li G，Dong L，Lan F，Sun Y，Zhang Z，Yang Z，Yu Y，Huang Y，He D，Xi Y，Wei D，Qi Q，Li W，Shi J，Wang M，Xie F，Wang J，Zhang X，Wang P，Zhao Y，Li N，Yang N，Dong W，Hu S，Zeng C，Zheng W，Hao B，Hillier LW，Yang S-P，Warren WC，Wilson RK，Brandström M，Ellegren H，Crooijmans R P M A，Poel J J V D，Bovenhuis H，Groenen M a M，Ovcharenko I，Gordon L，Stubbs L，Lucas S，Glavina T，Aerts A，Kaiser P，Rothwell L，Young J R，Rogers S，Walker BA，Hateren AV，Kaufman J，Bumstead N，Lamont SJ，Zhou H，Hocking PM，Morrice D，Koning D-J D，Law A，Bartley N，Burt DW，Hunt H，Cheng HH，Gunnarsson U，Wahlberg P，Andersson L，Kindlund E，Tammi MT，Andersson B，Webber C，Ponting CP，Overton IM，Boardman PE，Tang H，Hubbard SJ，Wilson SA，Yu J，Wang J，Yang H，Consortium I C P M (2004). "A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms." Nature, 432(7018): 717-722.

57. Jin W，Chen C，Zhang Y，Zhao Y，Feng J，Chen F，Wu Q，Yang H，Wang M，Yu J，Li N，Gong Y，Sun Q，Chen Z (2004). "Genome sequencing and characterization analysis of a Beijing isolate of chicken coronavirus infectious bronchitis virus." Chinese Science Bulletin, 49(6): 585-590.

58. 李文海, 邓学梅, 李宁, 王少华, 赵毅强, 杜正霖, 张然, 吴克亮, 吴常信 (2005). "SSH法结合定量PCR技术研究双肌臀猪肌肉组织的差异表达基因." 生物化学与生物物理进展.

59. 李小俊, 李欣, 陈晓丽, 赵毅强, 路永强, 王栋 (2018). "奶牛精子变形期间Pld6基因表达及蛋白序列分析." 畜牧兽医学报.

60. 李欣, 李小俊, 陈晓丽, 赵毅强, 王栋 (2019). "转录组数据分析与功能基因挖掘." 畜牧兽医学报.

61. 卜李那, 赵毅强 (2019). "全基因组关联分析及其扩展方法的研究进展." 农业生物技术学报.

62. 李飒, 赵毅强 (2019). "基因表达数据批次效应去除方法的研究进展." 南京农业大学学报.

63. 王宇占, 赵毅强 (2019). "基因组水平的选择信号及其检测方法研究进展." 家畜生态学报.

64. 卜李那, 彭业博, 张春媛, 刘洋秀, 赵毅强 (2020). "基于祖源分析的猪遗传成分鉴定." 中国畜牧兽医.

65. 王琦, 朱迪, 王宇哲, 吴杰, 胡晓湘, 赵毅强 (2020). "全基因组SNP分型策略及基因组预测方法的研究进展." 畜牧兽医学报.

66. 文子龙, 赵毅强 (2021). "群体遗传学下动物驯化研究进展." 遗传.

67. 赵毅强, 蔡新宇, 秦朝秋, 高秉铮, 徐君怡 (2021). "森林转基因林木抽样策略的研究." 生物技术进展.

68. 蔡新宇, 毛晓伟, 赵毅强 (2022). "家养动物驯化起源的研究方法与进展." 生物多样性.

获奖情况

承担项目及课题

专利情况

1.一种利用全基因组测序数据鉴定转基因事件的方法

2.CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置

社会兼职