| 何群 | |||||||||||
|
|||||||||||
教师简介
何群 中国农业大学生物学院微生物学及免疫学系教授。 学习与工作经历 学习经历： 研究方向 粗糙脉胞菌DNA甲基化及组蛋白修饰影响基因表达的机制 粗糙脉孢菌生物钟调控的分子遗传机制 主讲课程 《分子生物学》、《分子细胞生物学》 联系方式 电话：010-62731206 代表性论文（* 通讯作者） 2020 Courtney AJ, Kamei M, Ferraro AR, Gai K, He Q, Honda S, Lewis ZA. (2020) Cui G, Dong Q, Duan J, Zhang C, Liu X*, He Q*. (2020) NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition. Nucleic Acids Res. 2020 Jul 7; gkaa552. doi: 10.1093/nar/gkaa552. Online ahead of print. Wang T, Wang X, Zhu X, He Q, Guo L*. (2020) A proper PiCAT2 level is critical for sporulation, sporangium function, and pathogenicity of Phytophthora infestans. Mol Plant Pathol. 2020 Apr; 21(4):460-474. doi: 10.1111/mpp.12907. Epub 2020 Jan 29. He L, Guo W, Li J, Meng Y, Wang Y, Lou H, He Q*. (2020) Two dominant selectable markers for genetic manipulation in Neurospora crassa. Curr Genet. 2020 Mar 9. doi: 10.1007/s00294-020-01063-1. Online ahead of print. 2019 Li X, Liu Q, Sun W, He Q*, Tian C*. (2019) Improving cellulases production by Myceliophthora thermophila through disruption of protease genes. Biotechnol Lett. 2019 Dec 4. doi: 10.1007/s10529-019-02777-0. [Epub ahead of print] Lin L, Wang S, Li X, He Q, Benz JP, Tian C*. (2019) STK-12 acts as a transcriptional brake to control the expression of cellulase-encoding genes in Neurospora crassa. PLoS Genet. 2019 Nov 25;15(11):e1008510. doi: 10.1371/journal.pgen.1008510. [Epub ahead of print] Duan J, Liu Q, Su S, Cha J, Zhou Y, Tang R, Liu X, Wang Y, Liu Y, He Q*. (2019) The Neurospora RNA polymerase II kinase CTK negatively regulates catalase expression in a chromatin context-dependent manner. Environ Microbiol. 2019 Oct 9. doi: 10.1111/1462-2920.14821. [Epub ahead of print] Liu X, Chen A, Caicedo-Casso A, Cui G, Du M, He Q, Lim S, Kim HJ, Hong CI, Liu Y*. (2019) FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora. Nat Commun. 2019 Sep 25;10(1):4352. doi: 10.1038/s41467-019-12239-w. 周孟孟，周祎珂，苏德格日乐，王颖，何群*, 粗糙脉孢菌及其他真菌中生物钟系统研究进展. 菌物研究，2019，17（3/4）：155-166. 2018 Cao, X. ¶, X. Liu ¶, H. Li, Y. Fan, J. Duan, Y. Liu and Q. He*. (2018) Transcription factor CBF-1 is critical for circadian gene expression by modulating WHITE COLLAR complex recruitment to the frq locus. PLoS Genet. 2018 Sep 12;14(9):e1007570. doi: 10.1371/journal.pgen.1007570. eCollection 2018 Sep. Dong Q, Wang Y, Qi S, Gai K, He Q, Wang Y*. (2018) Histone variant H2A.Z antagonizes the positive effect of the transcriptional activator CPC1 to regulate catalase-3 expression under normal and oxidative stress conditions. Free Radic Biol Med. 2018 Jun;121:136-148. doi: 10.1016/j.freeradbiomed.2018.05.003. Epub 2018 May 5. Qi S, He L, Zhang Q, Dong Q, Wang Y, Yang Q, Tian C, He Q, Wang Y*. (2018) Cross-pathway control gene CPC1/GCN4 coordinates with histone acetyltransferase GCN5 to regulate catalase-3 expression under oxidative stress in Neurospora crassa. Free Radic Biol Med. 2018 Feb 5;117:218-227. doi: 10.1016/j.freeradbiomed.2018.02.003. Liu X, Li D*, Zhang D, Yin D, Zhao Y, Ji C, Zhao X, Li X, He Q, Chen R, Hu S*, Zhu L*. (2018) A novel antisense long noncoding RNA, TWISTED LEAF, maintains leaf blade flattening by regulating its associated sense R2R3-MYB gene in rice. New Phytol. 2018 Feb 7. doi: 10.1111/nph.15023. 2017 Liu Q, Zhou Y, Tang R, Wang X, Hu Q, Wang Y, He Q*. (2017) Increasing the unneddylated Cullin1 portion rescues the csn phenotypes by stabilizing adaptor modules to drive SCF assembly. Mol Cell Biol. 2017 Nov 13;37(23). pii: e00109-17. doi: 10.1128/MCB.00109-17. Print 2017 Dec 1. Liu X, Dang Y, Matsu-ura T, He Y, He Q, Hong CI, Liu Y*. (2017). DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Mol Cell, 67(2), 203-213.e4. doi:10.1016/j.molcel.2017.05.029 Wu Y, Zhang Y, Sun Y, Yu J, Wang P, Ma H, Chen S, Ma L, Zhang D, He Q, Guo J*. (2017) Up-Frameshift Protein UPF1 Regulates Neurospora crassa Circadian and Diurnal Growth Rhythms. Genetics, 206 (4): 1881-1893. doi: 10.1534/genetics.117.202788. Gai K, Cao X, Dong Q, Ding Z, Wei Y, Liu Y, Liu X, He Q*. (2017) Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function. PLoS Genet. 13(4):e1006732. doi: 10.1371/journal.pgen.1006732. 2016 Zeng M, Ren L, Mizuno K, Nestoras K, Wang H, Tang Z, Guo L, Kong D, Hu Q, He Q, Du L, Carr A*, Liu C*. (2016) CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nat Commun. doi: 10.1038/ncomms11364 Wang Y, Dong Q, Ding Z, Gai K, Han X, Kaleri FN, He Q, Wang Y*. (2016) Regulation of Neurospora Catalase-3 by global heterochromatin formation and its proximal heterochromatin region. Free Radic Biol Med. doi:10.1016/j.freeradbiomed.2016.07.019 Sun G, Zhou Z, Liu X, Gai K, Liu Q, Cha J, Kaleri FN, Wang Y, He Q*.(2016) Suppression of WHITE COLLAR-independent frequency Transcription by Histone H3 Lysine 36 Methyltransferase SET-2 is Necessary for Clock Function in Neurospora. J Biol Chem. 291(21): 11055-11063 doi: 10.1074/jbc.M115.711333 2015 刘青青，王颖，何群*，生物钟蛋白翻译后修饰的生物学功能，生命科学，2015，27（11）：1392-1402 王亚军，何群*，表观遗传研究的模式生物——粗糙脉孢菌，生物化学与生物物理进展，2015，24（11）：1026-1032 Liu X, Li H, Liu Q, Niu Y, Hu Q, Deng H, Cha J, Wang Y, Liu Y, He Q*. (2015) Role for protein kinase A in the Neurospora circadian clock by regulating White Collar-independent frequency transcription through phosphorylation of RCM-1. Mol Cell Biol. 35: 2088-2102 2014 Yang S, Li W, Qi S, Gai K, Chen Y, Suo J, Cao Y, He Y, Wang Y, He Q*. (2014) The highly expressed methionine synthase gene of Neurospora crassa is positively regulated by its proximal heterochromatic region. Nucleic Acids Res 42: 6183-6195. Zhang Z, Yang Q, Sun G, Chen S, He Q, Li S, Liu Y*. (2014) Histone H3K56 acetylation is required for quelling-induced small RNA production through its role in homologous recombination. J Biol Chem. doi: 10.1074/jbc.M113.528521 2013 Zhou Z, Liu X, Hu Q, Zhang N, Sun G, Cha J, Wang Y, Liu Y, He Q*. (2013) Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc. Natl. Acad. Sci. USA: E4867-E4874. doi/10.1073/pnas.1315133110 2012 Zhou Z, Wang Y, Cai G, He Q*. (2012) Neurospora COP9 Signalosome Integrity Plays Major roles for Hyphal Growth, Conidial Development, and Circadian Function. PLoS Genet. 8(5): e1002712. doi:10.1371/journal.pgen.1002712 2011 Li X, Shen Y, Sun J, Wang B*, He Q*. (2011) A Reporter for dsRNA response in Neurospora crassa. FEBS Letters 585(6): 906-912. 2010 Wang J, Hu Q, Chen H, Zhou Z, Li W, Wang Y, Li S*, He Q*. (2010) Role of Individual Subunits of the Neurospora crassa CSN Complex in Regulation of Deneddylation and Stability of Cullin Proteins. PLoS Genet. 6(12): e1001232. Xu H, Wang J, Hu Q, Quan Y, Chen H, Cao Y, Li C, Wang Y, He Q*. (2010) DCAF26, an Adaptor Protein of Cul4-Based E3, Is Essential for DNA Methylation in Neurospora crassa. PLoS Genet. 6(9): e1001132. doi:10.1371/journal.pgen.1001132 ZhaoY, Shen Y, Yang S, Wang J, Hu Q, Wang Y, He Q*. (2010) Ubiquitin ligase components Cullin4 and DDB1 are essential for DNA methylation in Neurospora crassa. J Biol Chem. 285: 4355-4365. First Published on November 30, 2009, doi:10.1074/jbc.M109.034710 He Q*, Tang C， Liu Y. (2010) The Roles of the Ubiquitin-Proteasome System in the Control of Circadian Clocks (Chapter 4). In “The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology”. Edited by Mario Di Napoli and Cezary Wojcik. Published by Nova Science Publishers. pp.53-68. 2007 Choudhary S, Lee H, Maiti M, He Q, Cheng P, Liu Q, Liu Y*. (2007) A Double-Stranded-RNA Response Program Important for RNA Interference Efficiency. Mol Cell Biol. 27: 3995-4005. 2006 He Q, Cha J, He Q, Lee H, Yang Y, Liu Y*. (2006) CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. Genes Dev. 20: 2552-2565 2005 He Q, Cheng P, He Q, Liu Y*. (2005) The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex. Genes Dev. 19: 1518-1531. He Q and Liu Y*. (2005) Degradation of the Neurospora circadian clock protein FREQUENCY through the ubiquitin-proteasome pathway. Biochem Soc Trans. 33:953-956. Cheng P, He Q, He Q, Wang L, Liu Y*. (2005) Regulation of the Neurospora circadian clock by an RNA helicase. Genes Dev. 19: 234-241. Liu Y*, Yang Y，He Q. (2005) Posttranscriptional regulation of the Neurospora circadian clock. In “Circadian Clocks in Eukaryotic Microbes”. Edited by Fred Kippert. Published by Landes Bioscience. (http://www.eurekah.com/abstract.php?chapid=2329&bookid=180&catid=85&PHPSESSID=4ca3afca5fc5f5d6da4e00fcc7abc154) 2004 Yang Y, He Q, Cheng P, Wrage P, Yarden O, Liu Y*. (2004) Distinct roles for PP1 and PP2A in the Neurospora circadian clock. Genes Dev. 18:255-260 He Q and You R*. (2004) Steedman’s wax sectioning for observation of the microtubule cytoskeleton in plant cells. Chinese Bulletin of Botany 21(5): 547-555. 2003 He Q﹟, Cheng P﹟, Yang Y, He Q, Yu H, Liu Y*. (2003) FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J. 22:4421-4430 He Q, You R*, MWANGE K N'K. (2003) Changes of the microtubule arrays during mitosis in prothallus cells of Dryospteris crassirhizoma. Acta Botanica Sinica 45(2):193-199. 2002 He Q, You R*, Sodmergen, Bao W. (2002) The preprophase band loses its function as a cytokinetic apparatus in mitosis of neck canal mother cell. Protoplasma 220: 105-109. 获奖情况 宝钢优秀教师奖（2019年） 政府特殊津贴（2016年） 荣获中国农业大学2018年度“优秀教师”荣誉称号 中国农业大学优秀班主任（2018年） 荣获2015届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生物学院毕业生——唐瑞琪 荣获2014届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生物学院毕业生——呼延佼奇 荣获2012届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生命科学试验班毕业生——孙卓 荣获2010届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生命科学试验班毕业生——孙巾荃 荣获2009届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生物学院毕业生——徐航 荣获2008届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生物学院毕业生——杨思璐 荣获2007届中国农业大学本科生“百篇优秀毕业论文（设计）”优秀指导教师奖。 生物学院毕业生——胥慧 荣获2012届中国农业大学校级优秀博士学位论文指导教师荣誉。 承担项目及课题 国家重点研发计划合成生物学专项，高版本工业丝状真菌底盘构建，2019.07-2024.06，课题一负责人 国家自然科学基金面上项目，粗糙脉孢菌中异染色质基因表达调控分子机制的研究，2018.01-2021.12，主持 国家自然科学基金重点项目，粗糙脉孢菌生物钟基因frq 转录抑制因子的筛选及其作用机制研究，2014.01-2018.12，主持 国家自然科学基金面上项目，脉孢菌中表观遗传修饰复合体介导的甲硫氨酸代谢调控分子机制的研究，2012.01-2015.12，主持 国家重大基础研究计划（973），生物钟在生殖系统与发育中调节的机制，2012.1-2016.12，课题3主持 国家自然科学基金面上项目， Tec1基因调控生物钟温度补偿的分子机制研究，2010.01-2012.12，主持 国家自然科学基金面上项目，脉孢菌WC-1和WC-2蛋白的化学修饰对生物钟系统调控的研究，2008.01-2010.12，主持 社会兼职 2015/06-2019/06 中国农业大学第五届校学术委员会委员 2016-2019 中国细胞生物学学会 生物节律分会 副会长 2020-2023 中国细胞生物学学会 生物节律分会 副会长 2017-2021 中国菌物学会理事，菌物遗传及分子生物学专业委员会 主任委员 2011/11-2016/10 《微生物学报》编委 2016/11-2021/10 《微生物学报》副主编 2014/01-2016/12 《遗传》编委 2017/01-2019/12 《遗传》编委 |
|||||||||||
| 【打印本页】 【关闭本页】 |
