王献兵
发布日期:2018-09-18 浏览次数:  信息来源:生物学院

教师简介

姓名:王献兵            
性别:
系别:微生物学与免疫学
职称:教授
学位:博士

 










王献兵,中国农业大学生物学院微生物与免疫学系,农业生物技术国家重点实验室教授,博士生导师。主要从事植物病毒与寄主植物以及昆虫介体之间复杂性互作关系研究。2013年获得国家自然科学基金优秀青年科学基金,2017年入选北京市科技新星计划。近年来在PNAS(2010)、Plant Cell(2011,2020)、elife(2020)、New Phytologist(2019)、PLoS Pathogens(2017)、Plant Physiology(2017)、Journal of Experimental Botany (2019, 2020)、Molecular Plant Pathology(2016)等期刊上发表多篇研究论文。


学习与工作经历

1999/09-2003/06,中国农业大学,生物科学专业,理学学士学位

2003/09-2009/06,中国农业大学,生物化学与分子生物学,理学博士学位

2007/10-2009/12,美国加州大学河滨分校,植物病理系,访问博士生

2009/12-2012/06,美国加州大学河滨分校,植物病理系,博士后

2012/07-至今,中国农业大学生物学院教授

研究方向

重大虫传植物病毒病害是制约我国粮食等作物高产稳产的重要因素,严重威胁着我国粮食安全和农业可持续发展。本课题组主要从事植物病毒与植物寄主或昆虫介体的互作机理等应用基础研究。具体研究主要包括:(1) 细胞质弹状病毒大麦黄条点花叶病毒(BYSMV)——小麦、玉米等农作物——灰飞虱介体三者的复杂性互作关系;(2) 黄瓜花叶病毒(CMV)——模式植物拟南芥之间侵染与防御的分子机制;(3) 从抗感性品种材料分离鉴定抗感病相关基因;(4) 以CMV和BYSMV为基础的病毒载体及相关生物反应器。


主讲课程

本科生《非编码RNA生物学》

研究生《分子病毒学》


联系方式

电话:010-62733313

邮件:wangxianbing[at]cau.edu.cn
通讯地址:北京市海淀区圆明园西路2号中国农业大学西校区生命科学研究中心


代表性文章 (#共同第一作者,*通讯作者)

1.Zang, Y., Fang, X.D., Qiao, J.H., Gao, Q., Wang, X-B.* (2020). Reverse genetics systems of plant negative-strand RNA viruses are difficult to be developed but powerful for virus-host interaction studies and virus-based vector applications. Phytopathology Research, 2, 29. https://doi.org/10.1186/s42483-020-00068-5.

2. Chai, L.X., Dong, K., Liu, S.Y., Zhang, Z., Zhang, X.P., Tong, X., Zhu, F.F., Zou, J.Z., Wang, X-B.* (2020). A putative nuclear copper chaperone promotes plant immunity in Arabidopsis. Journal of Experimental Botany. eraa401, https://doi.org/10.1093/jxb/eraa401.

3. Gao, Q.#, Yan, T.#, Zhang, Z.-J.#, Liu, S.-Y., Fang, X.-D., Gao, D.-M., Yang, Y.-Z., Xu, W.-Y., Qiao, J.-H., Cao, Q., Ding, Z.H., Wang,Y., Yu, J.L., Wang, X-B.* (2020). Casein Kinase 1 Regulates Cytorhabdovirus Replication and Transcription by Phosphorylating a Phosphoprotein Serine-rich Motif. Plant Cell, 32(9), 2878-2897.

4. Zhang, Z.J., Gao, Q., Fang, X.D., Ding, Z.H., Gao, D.M., Xu, W.Y., Cao, Q., Qiao, J.H., Yang, Y.Z., Han, C., Wang,Y., Yuan, X., Li, D., Wang, X-B.* (2020). CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication. eLife, 9, e53753

5. Gao, Q#, Xu, W-Y#, Yan, T, Fang, X-D, Cao, Q, Zhang, Z-J, Ding, Z-H, Wang, Y, Wang, X-B.* (2019). Rescue of a plant cytorhabdovirus as versatile expression platforms for planthopper and cereal genomic studies. New Phytologist, 223, 2120-2133.

6. Fang X-D#, Yan T#, Gao Q#, Cao Q, Yan T, Xu W-Y, Gao D-M, Zhang Z-J, Ding Z-H, Wang, X-B.* (2019). A cytorhabdovirus phosphoprotein forms mobile inclusions trafficking on the actin/ER network for viral RNA synthesis. Journal of Experimental Botany, 70, 4049-4062.

7. Zhang Z, Tong X, Liu SY, Chai LX, Zhu FF, Zhang XP, Zou JZ, Wang, X-B.* (2019). Genetic analysis of a Piezo-like protein suppressing systemic movement of plant viruses in Arabidopsis thaliana. Sci Rep 9(1): 3187.

8. Cao, Q., Xu, W.-Y., Gao, Q., Jiang, Z.-H., Liu, S.-Y., Fang, X.-D., Gao, D.-M., Wang, Y., Wang, X-B.* (2018). Transmission characteristics of barley yellow striate mosaic virus in its planthopper vector Laodelphax striatellus. Frontiers in microbiology 9, 1419.

9. Guo, Z.#Wang, X.B.#*, Wang, Y., Li, W.-X., Gal-On, A., and Ding, S.-W.* (2017). Identification of a new host factor required for antiviral RNAi and amplification of viral siRNAs. Plant Physiol. 176, 1587-1597.

10. Zhang, X.-P.#, Liu, D.-S.#, Yan, T., Fang, X.-D., Dong, K., Xu, J., Wang, Y., Yu, J.-L., and Wang, X.B.* (2017). Cucumber mosaic virus coat protein modulates the accumulation of 2b protein and antiviral silencing that causes symptom recovery in planta. PLoS pathogens 13, e1006522.

11. Wu, D., Qi, T., Li, W.X., Tian, H., Gao, H., Wang, J., Ge, J., Yao, R., Ren, C., Wang, X.B., Liu, Y., Kang, L., Ding, S.W., Xie, D., (2017). Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Res 27, 402-415.

12. Zhang, K., Zhang, Y., Yang, M., Liu, S., Li, Z., Wang, X-B., Han, C., Yu, J., Li, D., (2017). The barley stripe mosaic virus gammab protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes. PLoS Pathog 13, e1006319.

13. Dong, K.#, Wang, Y.#, Zhang, Z., Chai, L.X., Tong, X., Xu, J., Li, D., and Wang, X-B.* (2016). Two amino acids near the N-terminus of Cucumber mosaic virus 2b play critical roles in the suppression of RNA silencing and viral infectivity. Mol Plant Pathol 17, 173-183.

14. Xu, J., Liu, D., Zhang, Y., Wang, Y., Han, C., Li, D., Yu, J.-L., and Wang, X-B.* (2016). Improved pathogenicity of a beet black scorch virus variant by low temperature and co-infection with its satellite RNA. Frontiers in microbiology 7, 1771.

15. Yan, T., Zhu, J. R., Di, D., Gao, Q., Zhang, Y., Zhang, A,. Yan, C., Miao, H. and Wang, X-B.* 2015. Characterization of the complete genome of Barley yellow striate mosaic virus reveals a nested gene encoding a small hydrophobic protein. Virology 478:112-122.

16. Wang, X-B., Wu, Q., Ito, T., Cillo, F., Li, W.X., Chen, X., Yu, J.L., and Ding, S.W. 2010. RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. Proc Natl Acad Sci U S A 107:484-489.

17. Wang, X-B., Jovel, J., Udomporn, P., Wang, Y., Wu, Q., Li, W.X., Gasciolli, V., Vaucheret, H., and Ding, S.W. 2011. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. The Plant cell 23:1625-1638.

18. Cao M, Du P, Wang X.B., Yu YQ, Qiu YH, Li W, Gal-On A, Zhou C, Li Y, Ding SW. 2014. Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. Proc Natl Acad Sci U S A 111:14613-14618.

19. Xu, J., Wang, X.B., Shi, L., Zhou, Y., Li, D., Han, C., Zhang, Z., and Yu, J. 2012. Two distinct sites are essential for virulent infection and support of variant satellite RNA replication in spontaneous Beet black scorch virus variants. Journal of general virology 93:2718-2728.

20. Wu, Q., Wang, X.B., and Ding, S.W. 2010. Viral suppressors of RNA-based viral immunity: host targets. Cell host & microbe 8:12-15.

21. Qiao, Q.L., Liu, L., Xiong, Q., Flores, C., Wong, J., Shi, J., Wang, X.B., Liu, X., Jiang, S., Zhang, F., Wang, Y.C., Judelson, H.S., Chen, X.M. and Ma, W.B. 2013. Oomycete pathogens encode RNA silencing suppressors. Nature genetics 38:258-263.


获奖情况

2016年度中国植物病理学会青年植物病理学家奖


承担项目及课题

国家自然科学基金面上项目,31872920,大麦黄条点花叶病毒磷蛋白的致病机制分析,2019/01-2022/12,在研,主持

北京市科技新星,Z171100001117038,虫传病毒与昆虫介体特异识别的分子机制,2017/1-2019/12,已结题,主持

重点研发计划,2016YFC1200605,入侵生物致害与风险分析的分子标记与控制靶点,2016/7-2018/12,已结题,参加

国家自然科学基金面上项目,31571978,茎尖脱毒过程中黄瓜花叶病毒与寄主植物互作的分子机制,2016/01-2019/12,已结题,主持

国家自然科学基金面上项目,31370176,低温增强甜菜黑色叫苦病毒致病性的分子机制研究,2014/01-2017/12,已结题,主持

国家自然科学基金优秀青年科学基金,31322004,植物病毒学,2014/1-2016/12,已结题,主持

教育部博士点基金,20130008110029,黄瓜花叶病毒蛋白核定位对病毒致病性的影响,2014/1-2016/12,已结题,主持


专利情况


社会兼职

中国植物病理学会植物与病原物互作专业委员会副主任委员

【打印本页】 【关闭本页】