教师简介

姓名：	杨光辉
性别：	男
系别：	生物化学与分子生物学
职称：	教授
学位：	博士

　　杨光辉 博士，教授、博士生导师。2012和2017年先后获得中国农业大学学士、清华大学博士学位。2017-2019年在清华大学结构生物学高精尖创新中心从事博士后研究。2019年以“杰出人才”引进中国农业大学，任生物学院教授。

学习与工作经历

2008 – 2012 中国农业大学生物学院  本科

2012 – 2017 清华大学生命科学学院  博士

2017 – 2019 清华大学结构生物学高精尖中心  博士后

2019 – 至今 中国农业大学生物学院  教授

研究方向

1. 人类疾病相关蛋白质结构与功能的研究;

2. 通过研究重要农业作物性状相关蛋白质结构与功能，为改良农业作物品种提供线索。

发表文章

1. Zhou, R., Yang, G*., & Shi, Y. (2020). Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer’s disease. Current Opinion in Structural Biology, 61, 1-8. (*Corresponding author)

2. Zhou, R., Yang, G*., Guo, X., Zhou, Q., Lei, J., & Shi, Y. (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428), eaaw0930. 

(*Co-first author)

3. Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., ... & Shi, Y. (2019). Structural basis of Notch recognition by human γ-secretase. Nature, 565(7738), 192.

4. Zhou, R., Yang, G*., & Shi, Y. (2017). Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization. Proceedings of the National Academy of Sciences, 114(48), 12731-12736. (*Co-first author)

5. Yang, G., Zhou, R., & Shi, Y. (2017). Cryo-EM structures of human γ-secretase. Current opinion in structural biology, 46, 55-64.

6. Yu, X., Yang, G*., Yan, C., Baylon, J. L., Jiang, J., Fan, H., ... & Yan, N. (2017). Dimeric structure of the uracil: proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters. Cell research, 27(8), 1020. (*Co-first author and corresponding author)

7. Sun, L., Zhou, R., Yang, G., & Shi, Y. (2017). Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase. Proceedings of the National Academy of Sciences, 114(4), E476-E485.

8. Bai, X. C., Rajendra, E., Yang, G., Shi, Y., & Scheres, S. H. (2015). Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife, 4, e11182.

9. Bai, X. C., Yan, C., Yang, G*., Lu, P., Ma, D., Sun, L., ... & Shi, Y. (2015). An atomic structure of human γ-secretase. Nature, 525(7568), 212. (*Co-first author)

10. Sun, L., Zhao, L., Yang, G*., Yan, C., Zhou, R., Zhou, X., ... & Shi, Y. (2015). Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences, 112(19), 6003-6008. (*Co-first author)

11. Xie, T., Yan, C., Zhou, R., Zhao, Y., Sun, L., Yang, G., ... & Shi, Y. (2014). Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences, 111(37), 13349-13354.

12. Lu, P., Bai, X.C., Ma, D., Xie, T., Yan, C., Sun, L., Yang, G., Zhao, Y., Zhou, R., Scheres, S.H. and Shi, Y. (2014). Three-dimensional structure of human γ secretase. Nature, 512(7513), 166.

联系方式

电话：010-62731328

邮件：guanghuiyang at cau.edu.cn

通讯地址：北京市圆明园西路2号中国农业大学生物学院

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