Xianghui Ma, Yuhua Tian, Yongli Song, Jianyun Shi, Maksim V. Plikus, Lixiang Xue, and Zhengquan Yu. Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway. J Invest Dermatol. DOI: 10.1016/j.jid.
发布日期:2019-11-11 浏览次数:  信息来源:生物学院

Msi2 maintains quiescent state of hair follicle stem cells by directly repressing the Hh signaling pathway

Xianghui Ma, Yuhua Tian, Yongli Song, Jianyun Shi, Jiuzhi Xu, Kai Xiong, Jia Li, Wenjie Xu, Yiqiang Zhao, Jianwei Shuai, Lei Chen, Maksim V. Plikus, Christopher Lengner, Fazheng Ren, Lixiang Xue, and Zhengquan Yu

 

J Invest Dermatol

DOI: 10.1016/j.jid.

 

Abstract

Hair follicles (HFs) undergo precisely regulated cycles of active regeneration consisting of (anagen), involution (catagen), and relative quiescence (telogen) phases. HF stem cells (HFSCs) play important roles in regenerative cycling. Elucidating mechanisms that governs HFSC behavior can help uncover the underlying principles of hair development, hair growth disorders and skin cancers. RNA-binding proteins of the Musashi (Msi) have been implicated in the biology of different stem cell types, yet they have not been studied in HFSCs. Here we utilized gain- and loss-of-function mouse models to demonstrate that forced MSI2 expression retards anagen entry and consequently, delays hair growth, while loss of Msi2 enhances hair regrowth. Further, our findings show that Msi2 maintains quiescent state of HFSCs in the process of telogen-to-anagen transition. At the molecular level, our unbiased transcriptome profiling shows that Msi2 represses Hh signaling activity and that Shh is its direct target in the HF. Taken together, our findings reveal the importance of Msi2 in suppressing hair regeneration and maintaining HFSC quiescence. Previously unreported Msi2-Shh-Gli1 pathway adds to the growing understanding of the complex network governing cyclic hair growth.

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