2019年9月3日学术报告:Small RNAs: big roles in germline genome defense and fertility | |||||||
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2019年9月3日学术报告
Small RNAs: big roles in germline genome defense and fertility
报告时间:2019年9月3日 上午 10:00-11:30 报告地点:生命科学研究中心 2018会议室 报告人:Dr. Chen Chen
Dr. Chen Chen 简介 Associate ProfessorDepartment of Animal Science,Michigan State UniversityDegree:BS, China Agricultural University MS, Texas A&M University PhD, Washington University School of Medicine Postdoc, University of Toronto ResearchAffiliationsReproductive & Developmental Sciences Programs (RDSP)Laboratory: Germ Cell Biology Dr. Chen’s laboratory studies the molecular mechanisms underlying mammalian spermatogenesis and infertility using molecular, cellular, biochemical, mouse genetics and genomics approaches. The lab is broadly interested in genes and pathways influencing germ/stem cell self-renewal, differentiation and fertility with a current focus on the function of Tudor domain proteins and other Piwi-piRNA pathway associated factors in gene silencing, genome stability, epigenetics, stem cell biology and cancer.
Selected Publications Ding D, Liu J, Dong K, Melnick A, Latham KE, Chen C. Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis. Nucleic Acids Res. 2019 Mar 18;47(5):2594-2608. doi: 10.1093/nar/gky1281. Ding D, Liu J, Midic U, Wu Y, Dong K, Melnick A, Latham KE, Chen C. TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice. Nat Commun. 2018 Jan 9;9(1):127. doi: 10.1038/s41467-017-02622-w. Ding D, Liu J, Dong K, Midic U, Hess RA, Xie H, Demireva EY, Chen C. PNLDC1 is essential for piRNA 3’ end trimming and transposon silencing during spermatogenesis in mice. Nat Commun. 2017 Oct 10;8(1):819. doi: 10.1038/s41467-017-00854-4. Chen C*, Nott TJ, Jin J, Pawson T*. Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):629-42. *Corresponding author. Liu K*, Chen C*, Guo Y*, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18398-403. *Equal contribution. Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T. Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41. Jin J, Xie X*, Chen C*, Park JG, Stark C, James DA, Olhovsky M, Linding R, Mao Y, Pawson T. Eukaryotic protein domains as functional units of cellular evolution. Science Signaling. 2009 Nov 24;2(98):ra76. *Equal contribution. Chen C, Ouyang W, Grigura V, Zhou Q, Lim H, Zhao GQ, Carnes K, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann M, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature. 2005 August 18; 436:1030-34.
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