| 张华 | |||||||||||
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张华 生理学博士，中国农业大学教授，博士生导师。Biol Reprod、Animal Model and Experimental Medicine等杂志编委。多年从事雌性生殖特别是卵巢卵泡发育研究，课题组聚焦于卵泡发生发育激活的上下游调控机制，采用动物模型结合细胞生物学研究手段，目标揭示卵巢中卵泡有序发育的生理-细胞及分子调控机理，凝练通过人为调控卵泡发育进程克服生殖衰老不孕不育的可能方法。相关工作发表于Nat Med、Nat Commun、PNAS、Curr Biol等国际刊物。 学习与工作经历 1999.9-2003.6 中国农业大学生物学学士 2003.9-2008.12 中国农业大学生理学博士 2010.6-2011.12 瑞典于默奥大学博士后研究员 2012.1-2015.6 瑞典哥德堡大学研究人员 2015.6-至今 中国农业大学教授 研究方向 现代社会人类生育障碍问题日益突出，而卵巢作为女性生殖的核心器官，担负着卵子发生和激素分泌的重要功能。作为雌性动物生殖的基本功能单位，卵巢中的卵泡（Follicles）发生发育以及激活直接决定了雌性个体的生育力以及生育寿命：在生理情况下，卵泡随着年龄增长而有序的损耗，最终导致了人类的绝经以及其他雌性哺乳动物的生殖衰老；而其发育的异常直接导致卵巢早衰等女性生殖疾病。本课题组聚焦于卵泡发生发育激活的上下游调控机制，采用动物模型结合细胞生物学研究手段，目标揭示卵巢中卵泡有序发育的生理-细胞及分子调控机理，凝练通过人为调控卵泡发育进程克服生殖衰老不孕不育的可能方法。本实验室主要期望回答的问题如下： 主讲课程 《动物学》、《文献研读与报告》、《发育生物学专题》 发表文章 First/Co-first(#) & Corresponding /Co-corresponding author (*) 1. Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis. Niu S, Cheng K, Jia L, Liang J, Mu L, Wang Y, Yang X, Yang C, Zhang Y, Wang C, Huang L, Wang H, Zhang S, Zhang H*. Cell Death Differ. 2023 Feb 23. 2. In vivo promotion of primordial follicle activation by stem cell factor treatment in mice with premature ovarian insufficiency and advanced age. Wang Y, Zhang J, Liang J, Jia L, Niu S, Cheng K, Yang C, Lu Z, Mu L, Yang X, Zhang Y, Zhang H*. Mol Hum Reprod. 2022 Dec 28;29(1). 3. Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice. Dai Y, Bo Y, Wang P, Xu X, Singh M, Jia L, Zhang S, Niu S, Cheng K, Liang J, Mu L, Geng K, Xia G, Wang C, Zhang Y, Zhang H*. BMC Biol. 2022 May 13;20(1):109. 4. Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging. Xu X, Mu L, Li L, Liang J, Zhang S, Jia L, Yang X, Dai Y, Zhang J, Wang Y, Niu S, Xia G, Yang Y, Zhang Y, Cao Y, Zhang H*. Sci Adv. 2022 Jan 14;8(2) 5. Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice. Yan Zhang, Ye Wang, Xie’an Feng, Shuo Zhang, Xueqiang Xu, Lingyu Li, Shudong Niu, Yingnan Bo, Chao Wang, Zhen Li, Guoliang Xia, Hua Zhang*. Nat Commun. 2021 May 05;12, 2523. 6. In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human. Jiawei Zhang, Lei Yan, Yibo Wang, Shuo Zhang, Xueqiang Xu, Yanli Dai, Shidou Zhao, Zhen Li, Yan Zhang, Guoliang Xia, Yingying Qin*, Hua Zhang*. Clin Transl Med. 2020 Sep;10(5):e182. 7. 哺乳动物卵巢卵泡发育调控机制研究进展，张焱，张华*. 生理学报，2020.72（01） 8. Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice. Hao Yan, Jia Wen, Tuo Zhang, Wenying Zheng, Meina He, Kun Huang, Qirui Guo, Qian Chen, Yi Yang, Guangcun Deng, Jinrui Xu, Zhiqing Wei, Hua Zhang*, Guoliang Xia*, Chao Wang*. Cell Death Dis. 2019 Feb 15;10(3):160. 9. CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes. Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tongtong Zhao, Yanli Dai, Yan Zhang Y, Chao Wang, Yingying Qin, Guoliang Xia*, Hua Zhang*. BMC Biol. 2018 Jul 5;16(1):73. 10. ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice. Lizhao Feng L, Yijing Wang, Han Cai, Guanghong Sun, Wanbao Niu, Qiliang Xin, Xiaofang Tang, Jiawei Zhang, Chao Wang, Hua Zhang*, Guoliang Xia*. J Cell Sci. 2016 Jun 1;129(11):2202-12. (封面文章) 11. Yijing Wang, Zhen Teng, Ge Li, Xinyi Mu, Zhengpin Wang, LizhaoFeng, WanbaoNiu, Kun Huang, Xi Xiang, Chao Wang, Hua Zhang#, Guoliang Xia#. Cyclic AMP in oocytes controls meiotic prophase І and primordial folliculogenesis in the perinatal mouse ovary. Development. 2015 Jan 15;142(2):343-51. 12. Zhang H*, Panula S*, Petropoulos S, Edsgärd D, Busayavalasa K, Liu L, Li X, Risal S, Shen Y, Shao J, Liu M, Li S, Zhang D, Zhang X, Gerner RR, Sheikhi M, Damdimopoulou P, Sandberg R, Douagi I, GustafssonJÅ, Liu L, Lanner F, Hovatta O, Liu K. Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nat Med. 2015 Oct 7;21(10):1116-8. doi: 10.1038/nm.3775. 13. Hua Zhang#, Kui Liu#. Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood. Hum Reprod Update. 2015 Jul 30.pii: dmv037. Review. 14. Hua Zhang*, Lian Liu*, Xin Li, KiranBusayavalasa, Yan Shen, OutiHovatta, Jan-ÅkeGustafsson, and Kui Liu. Life-long in vivo cell lineage tracing shows that initial follicle pool is the only source of mature eggs in adult mice. PNAS. 2014 Dec 16;111(50):17983-8. 15. Hua Zhang*, SanjivRisal, NagarajuGorre, KiranBusayavalasa, Xin Li, Yan Shen, Mats Brännström, and Kui Liu. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Current Biology, 2014 Nov 03; 24(21):2501-8. 16. WenjingZheng*, Hua Zhang*, GorreNajaraju, SanjivRisal, Yan Shen, Kui Liu. Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions. Hum Mol Genet. 2014 Feb 15;23(4):920-8 17. Hua Zhang*, Deepak Adhikari, WenjingZheng, and Kui Liu. Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells. Reproduction, 2013 Oct 21;146(6):R229-33. Review. 18. Hua Zhang*, WenjingZheng*, Yan Shen, Deepak Adhikari, and Kui Liu.Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. PNAS, 2012 Jul 31;109(31):12580-5 19. Hua Zhang*, BaoshanXu*, HuirongXie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li, Meijia Zhang and Guoliang Xia. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. Molecular Reproduction and Development. 2009 May;76:514-21. Contributing author (Recently) 1. JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice. Wanbao Niu, Ye Wang, Zhengpin Wang, Qiliang Xin, Yijing Wang, Lizhao Feng, Lihua Zhao, Jia Wen, Hua Zhang, Chao Wang, Guoliang Xia*. Development. 2016 May 15;143(10):1778-87. 2. GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice. Jia Wen, Hao Yan, Meina He, Tuo Zhang, Xinyi Mu, Huarong Wang, Hua Zhang, Guoliang Xia, Chao Wang*. BMC Biol. 2019 Mar 12;17(1):23. 3. HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge. Huarong Wang, Han Cai, Xiao Wang, Meiling Zhang, Bingying Liu, Ziqi Chen, Tingting Yang, Junshun Fang, Yanhao Zhang, Wei Liu, Jun Han, Qirui Guo, Hua Zhang, Haibin Wang, Guoliang Xia, Chao Wang*. Nat Commun. 2019 Dec 16;10(1):5719. 4. LSD1 contributes to programmed oocyte death by regulating the transcription of autophagy adaptor SQSTM1/p62. Meina He, Tuo Zhang, Zijian Zhu, Shaogang Qin, Huarong Wang, Lihua Zhao, Xinran Zhang, Jiayi Hu, Jia Wen, Han Cai, Qiliang Xin, Qirui Guo, Lin Lin, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wang*. Aging Cell. 2020 Mar;19(3):e13102. 5. SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice. Han Cai, Bingying Liu, Huarong Wang, Guanghong Sun, Lizhao Feng, Ziqi Chen, Jiaqi Zhou, Jiawei Zhang, Tuo Zhang, Meina He, Tingting Yang, Qirui Guo, Zhen Teng, Qiliang Xin, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wang*. J Mol Cell Biol. 2020 Apr 24;12(3):230-244. 联系方式 电话：010-62734107 邮箱：huazhang at cau.edu.cn 获奖情况 2017 中国动物学会青年科技奖 2015 中国生理学会生殖分会青年科技奖 承担项目及课题 2022年，国家自然科学基金委重点项目 2019年，国家自然科学基金委面上项目 2018年，科技部重点研发计划（课题负责人） 2017年，科技部重点研发计划（骨干） 2016年，国家自然科学基金委面上项目 专利情况 获得国家发明专利1项 社会兼职 中国动物学会生殖科学分会常务理事 中国畜牧兽医学会生理生化分会理事 Biology of Reproduction杂志编委 Animal model and experimental medicine杂志编委 中华生殖与避孕杂志编委 |
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