教师简介

姓名：	于舒洋
性别：	男
系别：	生物化学与分子生物学
职称：	教授
学位：	博士

于舒洋 博士，教授；年龄：45岁 出生年月：1978年8月
2000-2005年：博士，中国农业大学生物学院；
2005-2013年：博士后，Research Scientist，瑞典卡罗林斯卡医学院、美国范德堡大学、美国爱荷华大学；
2014年至今：中国农业大学生物学院 教授 博导

简历

2000年毕业于中国农业大学生物学院获得理学学士学位；同年进入农业生物技术国家重点实验室攻读博士并于2005年6月获得理学博士学位。先后在瑞典Karolinska Institute，美国Vanderbilt University和University of Iowa从事博士后研究工作。2010年5月受聘于University of Iowa作为Assistant Research Scientist从事造血干细胞和分子免疫学的研究。2014年以“拔尖人才”引进中国农业大学，任生物学院教授、博士生导师。 

申请人长期从事 T 细胞和造血干细胞（HSC）的分化及功能研究，获得国家“优青”等人才项目资助；主持科技部重点研发计划“干细胞”专项课题，主持国家自然基金“重点”和“面上”项目。主要学术成绩包括：1）发现 TCF-1 时序性调控胸腺 T 细胞分化并抑制 T 细胞肿瘤发生；2） 阐明 SRSF1 转录后调控 T 细胞和 iNKT 细胞的发育分化的机制；3）揭示 m6A 甲基化和磷酸激酶 PDK1 调控 Tfh 细胞的分化和功能；4）解析 Wnt 通路相关分子和 GABP 因子调控 HSC 的分化。申请人以通讯（含共同）、第一作者（含共同）发表论文 28 篇，包括 Immunity、Nature Immunology、Cell Stem Cell、Blood、Science Advances、Nature Communications、Elife、Cell Reports、Cellular & Mollecular Immunology、Science Bulletin和Protein Cell等权威期刊。

学习与工作经历

教育经历

1996.09－2000.07：中国农业大学生物学院，攻读学士学位

2000.09－2005.03：中国农业大学生物学院，攻读博士学位

工作经历

2005.03-2007.03：博士后，Department of Laboratory Medicine, Karolinska Institute. Sweden

2007.04-2007.12：博士后, Department of Reproductive Biology, Vanderbilt University. USA

2007.12-2010.05：博士后, University of Iowa, Carver College of Medicine. USA

2010.05-2013.03：助理研究科学家（Assistant Research Scientis）, University of Iowa. USA 

2013.05-至今：中国农业大学生物学院 教授、博士生导师

研究方向

1、围绕HSC和血液系统中具有重要功能的成熟细胞亚群的分化发育：

• 利用多种基因修饰小鼠模型分析重要的功能基因和信号通路对HSC自我更新和分化发育的分子机制；

• 转录因子及RNA结合蛋白在T细胞、B细胞、NK细胞等淋巴细胞中的功能和调控机理；RNA结合蛋白介导的mRNA表观修饰（m6A，m5C）在淋巴细胞分化发育、免疫应答和记忆形成过程中的功能和机制研究；

• GABP和TCF/LEF转录因子的互作蛋白和复合物在HSC及成熟血细胞发育分化中的调控机制；

2、利用人源化小鼠模型研究干细胞移植后免疫原性及免疫应答机制。

主讲课程

本科生 《遗传学》

研究生 《动物科学seminar》

发表文章

First/Co-first (#) & Corresponding/Co-corresponding author (*)

1. You M#, Liu J#, Li J#, Ji C#, Ni H, Guo W, Zhang J, Jia W, Wang Z, Zhang Y, Yao Y, Yu G, Ji H, Wang X, Han D, Du X*, Xu MM*, Yu S*. Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation. Cell Rep. 2023 Jun 1;42 (6):112584. doi: 10.1016/j.celrep.2023.112584.

2. Ji C#, Bao L#, Yuan S#, Qi Z, Wang F, You M, Yu G, Liu J, Cui X, Wang Z, Liu J, Guo W, Feng M, Chen F, Kang Y*, Yu S*. SRSF1 Deficiency Impairs the Late Thymocyte Maturation and the CD8 Single-Positive Lineage Fate Decision. Front Immunol. 2022 Jan; 26 (13) 1664- 3224. doi: 10.3389/fimmu.2022.838719.

3. Liu J #, Wang Z #, Hao S #, Wang F, Yao Y, Zhang Y, Zhao Y, Guo W, Yu G, Ma X, Liu J, Chen F, Yuan S *, Kang Y*, Yu S*. Tcf1 sustains the expression of multiple regulators in promoting early natural killer cell development. Front Immunol. 2021 Nov; 30 (12): 791220. doi: 10.3389/fimmu.2021.791220. eCollection 2021.

4. Liu J#, You M#, Yao Y, Ji C, Wang Z, Wang F, Wang D, Qi Z, Yu G, Sun Z, Guo W, Liu J, Zhao T, Xue HH, Xue Y, Yu S*. SRSF1 plays a critical role in invariant natural killer T cell development and function. Cell Mol Immunol. 2021 Nov;18(11):2502-2515. doi: 10.1038/s41423-021-00766-w. Epub 2021 Sep 14.

5. Qi Z#, Wang F#, Yu G#, Wang D#, Yao Y, You M, Liu J, Liu J, Sun Zhen, Ji C, Xue Y, Yu S^*. SRSF1 serves as a critical post-transcriptional regulator at the late stage of thymocyte development. Sci. Adv. 2021 Apr 16;7(16): eabf0753. doi: 10.1126/sciadv.abf0753.

6. Yao Y#, Yang Y#, Xu L#, Guo W#, You M., Zhang Y.C, Sun Z, Cui X, Yu G, Qi Z, Liu J, Wang F, Liu J, Zhao T, Ye L*, Yang Y.G*, Yu S*. METTL3-dependent m6A modification programs T follicular helper cell differentiation. Nat. Commun. 2021 Feb 26;12(1):1333. doi: 10.1038/s41467-021-21594-6.

7. Sun Z#, Yao Y#, You M#, Liu J, Guo W, Qi Z, Wang Z, Wang F, Yuan W, and Yu S*. (2021). The kinase PDK1 is critical for promoting T follicular helper cell differentiation. Elife 10: e61406. doi:10.7554/eLife.61406

8. Wang F#, Qi Z#, Yao Y, Yu G, Feng T, Zhao T, Xue H-H, Zhao Y, Jiang P, Bao L, and Yu S*. Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single cell resolution. Cell Mol Immunol. 2021 Mar;18(3):644-659. doi: 10.1038/s41423-020-00527-1. Epub 2020 Aug 31.

9. Yuan X#, Qian N#, Ling S, Li Y, Sun W, Li J, Du R, Zhong G, Liu C, Yu G, Cao D, Liu Z, Wang Y, Qi Z, Yao Y, Wang F, Liu J, Hao S, Jin X, Zhao Y, Xue J, Zhao D, Gao X, Liang S, Li Y, Song J, Yu S* and Li Y*. Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics. 2021; 11(3):1429-1445. doi:10.7150/thno.45351. Online advance articles.

10. Yu G#, Wang F#, You M#, Xu T#, Shao C, Liu Y, Liu R, Deng M, Qi Z, Wang Z, Liu J, Yao Y, Chen J, Sun Z, Hao S, Guo W, Zhao T, Yu Z, Zhang Q, Zhao Y, Chen F*, Yu S*. TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation. Protein Cell. 2020; 11(5): 380-6.

11. Liu C#, Dai SK#, Sun Z#, Wang Z, Liu PP, Du HZ, Yu S*, Liu CM*, Teng ZQ*. GA-binding protein GABPbeta1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019; 39:101501.

12. Liu J#, Cui Z#, Wang F#, Yao Y, Yu G, Liu J, Cao D, Niu S, You M, Sun Z, Lian D, Zhao T, Kang Y, Zhao Y, Xue HH, Yu S*. Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells. FASEB J. 2019;33(4):5615-25.

13. Cao D#, Song J#, Ling S#, Niu S#, Lu L, Cui Z, Li Y, Hao S, Zhong G, Qi Z, Sun W, Yuan X, Li H, Zhao D, Jin X, Liu C, Wu X, Kan G, Cao H, Kang Y, Yu S*, Li Y*. Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions. FASEB J. 2019;33(6):6904-18.

14. Zhang T#, Cheng X#, Yu D#, Lin F, Hou N, Cheng X, Hao S, Wei J, Ma L, Fu Y, Ma Y, Ren L, Han H, Yu S*, Yang X*, Zhao Y*. Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice. Front Immunol. 2018 Sep 25 (9): 2202. doi: 10.3389/fimmu.2018.02202. eCollection 2018.

15. Yao Y#, Guo W#, Chen J#, Guo P#, Yu G, Liu J, Wang F, Liu J, You M, Zhao T, Kang Y, Ma X, Yu S*. Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection. RNA Biol. 2018;15(12):1477-86.

16. Zhang L#, Cui Z#, Zhou L, Kang Y, Li L, Li J, Dai Y, Yu S*, Li N*. Developing a Triple Transgenic Cell Line for High-Efficiency Porcine Reproductive and Respiratory Syndrome Virus Infection. PLoS One. 2016;11(5):e0154238.

17. Yu S#*, Li F#, Xing S, Zhao T, Peng W, Xue HH*. Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. J Biol Chem. 2016;291(21):11148-60.

18. Steinke FC#, Yu S#, Zhou X, He B, Yang W, Zhou B, Kawamoto H, Zhu J, Tan K, Xue HH. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nat Immunol. 2014;15(7):646-56.

19. Yu S*, Xue HH*. TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes. Blood. 2013;121(19):4008-9.

20. Yu S#, Zhou X#, Steinke FC, Liu C, Chen SC, Zagorodna O, Jing X, Yokota Y, Meyerholz DK, Mullighan CG, Knudson CM, Zhao DM, Xue HH. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity. 2012;37(5):813-26.

21. Yu S#, Zhou X, Hsiao JJ, Yu D, Saunders TL, Xue HH. Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Ralpha in T cells. Transgenic Res. 2012;21(1):201-15.

22. Yu S#, Jing X, Colgan JD, Zhao DM, Xue HH. Targeting tetramer-forming GABPbeta isoforms impairs self-renewal of hematopoietic and leukemic stem cells. Cell Stem Cell. 2012;11(2):207-19.

23. Yu S#, Cui K#, Jothi R#, Zhao DM, Jing X, Zhao K, Xue HH. GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood. 2011;117(7):2166-78.

24. Zhou X#, Yu S#, Zhao DM, Harty JT, Badovinac VP, Xue HH. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity. 2010;33(2):229-40.

25. Zhao DM#, Yu S#, Zhou X, Haring JS, Held W, Badovinac VP, Harty JT, Xue HH. Constitutive activation of Wnt signaling favors generation of memory CD8 T cells. J Immunol. 2010;184(3):1191-9. 

26. Yu S, Zhao DM, Jothi R, Xue HH. Critical requirement of GABPalpha for normal T cell development. J Biol Chem. 2010;285(14):10179-88.

27. Yu SY, Liang MF, Fan BL, Xu HT, Li C, Zhang QF, Li DX, Tang B, Li SJ, Dai YP, Wang ML, Zheng M, Yan BX, Zhu QH, Li N. Maternally derived recombinant human anti-hantavirus monoclonal antibodies are transferred to mouse offspring during lactation and neutralize virus in vitro. J Virol. 2006;80(8):4183-6.

28. Yu SY, Cao GS, Fan BL, Li N, Duan YL, Dai YP, Wang LL. The cloning of human alpha-lactalbumin gene and high-level expression in milk of transgenic mice. Prog Biochem Biophys. 2004;31(3):244-8. 

Contributing author

29. Li X, Zhang B, Zhang X, Yu S, Xue HH, Hu X. TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis. Mucosal Immunol. 2023 Feb;16(1):50-60. doi: 10.1016/j.mucimm.2022.12.005. Epub 2023 Jan 2.

30. Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J. METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis. Nat Cell Biol. 2022 Aug;24(8):1278-1290. doi: 10.1038/s41556-022-00968-y. Epub 2022 Aug 4.

31. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J, Zhang W, Liu GH. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell. 2022 Jun 2;29(6):990-1005.e10. doi: 10.1016/j.stem.2022.04.017. Epub 2022 May 24.

32. Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J. YTHDF1 promotes gastric carcinogenesis by controlling translation of FZD7. Cancer Res. 2020.

33. Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH. Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity. J Exp Med. 2018;215(8):2211-26.

34. Chen J, Cai Z, Bai M, Yu X, Zhang C, Cao C, Hu X, Wang L, Su R, Wang D, Wang L, Yao Y, Ye R, Hou B, Yu Y, Yu S, Li J, Xue Y. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Res. 2018;28(10):981-95.

35. Li F, He B, Ma X, Yu S, Bhave RR, Lentz SR, Tan K, Guzman ML, Zhao C, Xue HH. Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell Stem Cell. 2017;21(3):359-73 e5.

36. Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J. YTHDF1 promotes gastric carcinogenesis by controlling translation of FZD7. Cancer Res. 2020. PMID: 32788173

37. Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH. Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity. J Exp Med. 2018;215(8):2211-26. PMID: 30045946

38. Chen J, Cai Z, Bai M, Yu X, Zhang C, Cao C, Hu X, Wang L, Su R, Wang D, Wang L, Yao Y, Ye R, Hou B, Yu Y, Yu S, Li J, Xue Y. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Res. 2018;28(10):981-95. PMID: 30143796

39. Li F, He B, Ma X, Yu S, Bhave RR, Lentz SR, Tan K, Guzman ML, Zhao C, Xue HH. Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell Stem Cell. 2017;21(3):359-73 e5.

40. Xing S, Li F, Zeng Z, Zhao Y, Yu S, Shan Q, Li Y, Phillips FC, Maina PK, Qi HH, Liu C, Zhu J, Pope RM, Musselman CA, Zeng C, Peng W, Xue HH. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016;17(6):695-703.

41. He B, Xing S, Chen C, Gao P, Teng L, Shan Q, Gullicksrud JA, Martin MD, Yu S, Harty JT, Badovinac VP, Tan K, Xue HH. CD8(+) T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. Immunity. 2016;45(6):1341-54.

42. Han B, Yuan H, Wang T, Li B, Ma L, Yu S, Huang T, Li Y, Fang D, Chen X, Wang Y, Qiu S, Guo Y, Fei J, Ren L, Pan-Hammarstrom Q, Hammarstrom L, Wang J, Wang J, Hou Y, Pan Q, Xu X, Zhao Y. Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds. J Immunol. 2016;196(12):5138-47.

43. Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, Wang H, Wang X, Yu S, Zhou X, Cam M, Xue HH, Bhandoola A. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol. 2015;16(10):1044-50.

44. Carr T, Krishnamoorthy V, Yu S, Xue HH, Kee BL, Verykokakis M. The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. J Exp Med. 2015;212(5):793-807.

45. Xie W, Lynch TJ, Liu X, Tyler SR, Yu S, Zhou X, Luo M, Kusner DM, Sun X, Yi Y, Zhang Y, Goodheart MJ, Parekh KR, Wells JM, Xue HH, Pevny LH, Engelhardt JF. Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol. 2014;306(7):L645-60.

46. Zhao Y, Liu Z, Yu S, Wen S, Hammarstrom L, Rabbani H. Construction of a High Efficiency PCR Products Cloning T Vector Using pGEM-5zf (+). Avicenna J Med Biotechnol. 2009;1(1):37-9.

47. Xu HT, Fan BL, Yu SY, Huang YH, Zhao ZH, Lian ZX, Dai YP, Wang LL, Liu ZL, Fei J, Li N. Construct synthetic gene encoding artificial spider dragline silk protein and its expression in milk of transgenic mice. Anim Biotechnol. 2007;18(1):1-12.

48. Lu W, Zhao Z, Zhao Y, Yu S, Zhao Y, Fan B, Kacskovics I, Hammarstrom L, Li N. Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology. 2007;122(3):401-8.

49. Li S, Li Y, Yu S, Du W, Zhang L, Dai Y, Liu Y, Li N. Expression of insulin-like growth factors systems in cloned cattle dead within hours after birth. Mol Reprod Dev. 2007;74(4):397-402.

50. Li S, Li Y, Du W, Zhang L, Yu S, Dai Y, Zhao C, Li N. Aberrant gene expression in organs of bovine clones that die within two days after birth. Biol Reprod. 2005;72(2):258-65.

51. Yu Z, Li Y, Meng Q, Yuan J, Zhao Z, Li W, Hu X, Yan B, Fan B, Yu S, Li N. Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene. Sci China C Life Sci. 2005;48(2):168-80.

52. Xu HT, Zhao YF, Lian ZX, Fan BL, Zhao ZH, Yu SY, Dai YP, Wang LL, Niu HL, Li N, Hammarstrom L, Boren T, Sjostrom R. Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen. World J Gastroenterol. 2004;10(14):2063-6.

53. Duan YL, Yu SY, Li N. [The fast TnT isoforms specifically expressed in avian adult pectoral muscles of Galliforms and physiological significance]. Yi Chuan. 2002;24(6):699-706.

联系方式

电话：010-62733810

邮件：ysy at cau.edu.cn,

    yushuyang at hotmail.com

通讯地址：北京市圆明园西路2号中国农业大学生物学院

承担项目及课题

2021年，获得国家自然科学基金委“重点”项目资助 (主持)

2019年，获得国家自然科学基金委“面上”项目资助 (主持)

2017年，获得科技部重点研发“干细胞”专项资助 (主持)

2016年，获得国家自然科学基金委“重点”项目资助 (参加，占重1/3)

2015年，获得国家自然科学基金委“面上”项目资助 (主持)

2014年，获得国家自然科学基金委“优青”资助 (主持)

社会兼职

农业生物技术学会理事；

生物化学与分子生物学会青年委员；

中国干细胞协会衰老分会委员

中国医药教育协会转化医学专业委员会常务委员

多个学术期刊的特邀审稿人。