2021年6月15日(星期二)2:30-3:30pm 生命科学研究中心2018会议室 学术报告 Therapeutic potential of targeting dendritic cells in cancer immunotherapy
发布日期:2021-06-10 浏览次数:  信息来源:生物学院


题目:Therapeutic potential of targeting dendritic cells in cancer immunotherapy

主讲人:徐 研究员

时间:20216月15日(星期二)2:30-3:30pm

地点:生命科学研究中心2018会议

联系人:于舒洋            联系方式:62733810

 

 

主讲人简介

徐萌,清华大学医学院免疫所,研究员,博士生导师。获国家“***”青年项目及基金委优青项目支持。实验室主要围绕免疫细胞、肿瘤细胞及免疫微环境间的相互作用和命运决定机制展开研究,为免疫治疗提供新靶点和新型治疗策略。近年研究成果发表于Nature, Nature Medicine,Immunity等杂志。

代表论著:

1. Lihui Dong, Chuanyuan Chen, Yawei Zhang, Peijin Guo, Zhenghang Wang, Jian Li, Yi Liu, Jun Liu, Renbao Chang, Yilin Li, Guanghao Liang, Weiyi Lai, Mengxue Sun, Urszula Dougherty, Marc B. Bissonnette, Hailin Wang, Lin Shen, Meng Michelle Xu*, Dali Han*. The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth. Cancer Cell 2021. (In press)

2. Yi Liu, Guanghao Liang, Hongjiao Xu, Wenxin Dong, Ze Dong, Zhiwei Qiu, Zihao Zhang, Fangle Li, Yue Huang, Yilin Li, Jun Wu, Shenyi Yin, Yawei Zhang, Peijin Guo, Jun Liu, Jianzhong Jeff Xi, Peng Jiang, Dali Han*, Cai-Guang Yang*, Meng Michelle Xu*. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metabolism 2021,33:1221-1233

3. Dali Han*, Jun Liu, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, Urszula Dougherty, Marc B. Bissonnette, Bin Shen, Ralph R Weichselbaum, Meng Michelle Xu*, Chuan He*. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 2019, 566(7743):270-274.

4. Meng Michelle Xu, Yang Pu, Dali Han, Yaoyao Shi, Xuezhi Cao, Hua Liang, Xiang Chen, Xiao-Dong Li, Liufu Deng, Zhijian J. Chen, Ralph R. Weichselbaum, Yang-Xin Fu*. Dendritic cells but not macrophages sense tumor mitochondrial DNA for cross-priming through signal regulatory protein α signaling. Immunity 2017, 47(2):363-373.


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