教师简介

宋文 博士，教授，博士生导师。植物抗逆高效全国重点实验室课题组长。2018年博士毕业于清华大学，获理学博士学位。2018年-2023年在德国马克斯-普朗克研究所和科隆大学从事博士后研究。2023年以“杰出人才”引进中国农业大学，任生物学院教授。近年来，在植物免疫和小肽激素领域取得了一系列原创性研究成果，以（共同）第一作者/通讯作者在Nature, Science, Cell, Cell Research，Nature Plants, Nature Structural & Molecular Biology, Molecular Plant, Nature Communications等国际学术期刊上发表论文二十余篇。

学习与工作经历

教育背景

2009.09-2013.06 中国农业大学，农学与生物技术学院，学士

2013.09-2018.06 清华大学，生命科学学院，博士

2017.08-2018.04 德国科隆大学，生物化学研究所，访问博士

工作经历

2018.08-2023.07 德国马克斯-普朗克植物育种研究所，科隆大学生物化学研究所，博士后

2023.08-至今 中国农业大学，生物学院，教授

研究方向

本实验室关注植物与微生物、植物与环境的互作。以生物化学、结构生物学和遗传学为手段，探究植物受体介导的免疫反应和非生物胁迫应答的分子机制。同时也关注植物小分子、小肽激素参与的生长发育及免疫胁迫应答机制。

课题组长期欢迎本科生、博士生、博士后等热爱科研的青年学者加入！

联系方式

邮件 wensong at cau.edu.cn

通讯地址：北京市海淀区圆明园西路2号，中国农业大学生物学院，100193

发表文章（*Co-first author, ^#Corresponding author）

2024

1. Song W*, Liu L*, Yu D, Bernard H, Jirschitzka J, Hang S, Jia A, Jemleniak W, Acker J, Laessle H, Wang J, Shen Q, Chen W, Li P, Parker J, Han Z, Schulze-Lefert P, Chai J. (2024) Substrate-induced condensation activates plant TIR domain proteins. Nature 

2023

2. Chai J, Song W, Parker J. (2023) New biochemical principles for NLR immunity in plants. MPMI (H. H. FLOR DISTINGUISHED REVIEW) 36 (8), 468-475

3. Yu Y*, Song W*, Zhai N*, Zhang S, Wang J, Wang S, Liu W, Huang C, Ma H, Chai J, Chang F. (2023) PXL1 and SERKs act as receptor–coreceptor complexes for the CLE19 peptide to regulate pollen development. Nature communications 14 (1), 3307

4. Wang J^#, Song W^#, Chai J^#. (2023) Structure, biochemical function and signaling mechanism of plant NLRs. Molecular Plant 16 (1), 75-95

2022

5. Liu L*, Song W*, Huang S, Jiang K, Moriwaki Y, Wang Y, Men Y, Zhang D, Wen X, Han Z, Chai J, Guo H. (2022) Extracellular pH sensing by plant cell-surface peptide receptor complexes. Cell 185 (18), 3341-3355. e13

6. Yu D*, Song W*, Tan E *, Liu L, Cao Yu, Jirschitzka J, Li E, Logemann E, Xu C, Huang S, Jia A, Chang X, Han Z, Wu B, Schulze-Lefert P, Chai J. (2022) TIR domains of plant immune receptors are 2′, 3′-cAMP/cGMP synthetases mediating cell death. Cell 185 (13), 2370-2386. e18

7. Jia A*,  Huang S*, Song W*, Wang J*, Meng Y*, Sun Y*, Xu L, Laessle H, Jirschitzka J, Hou J, Zhang T, Yu W, Hessler G, Li E, Ma S, Yu D, Gebauer J,  Baumann U, Liu X, Han Z, Chang J, Parker J, Chai J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 377 (6605), eabq8180.

8. Huang S*, Jia A*, Song W*, Hessler G*, Meng Y*, Sun Y, Xu L, Laessle H, Jirschitzka J, Ma S, Xiao Y, Yu D, Hou J, Liu R, Sun H, Liu X, Han Z, Chang J, Parker J, Chai J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science 377 (6605), eabq3297

9. Qian P*, Song W*, Zaizen-Iida M, Kume S, Wang G, Zhang Y, Chai J, and Kakimoto T. (2022) A Dof-CLE circuit controls phloem organization. Nature Plants 8 (7):817-827

10. Gao H, Song W, Severing E, Vayssières A, Huettel B, Franzen R, Richter R, Chai J, Coupland G. (2022) PIF4 enhances DNA binding by CDF2 to co-regulate target gene expression and promote Arabidopsis hypocotyl cell elongation. Nature Plants 8 (9), 1082-1093

2021

11. Song W*, Forderer A*, Yu D*, Chai J. (2021) Structural biology of plant defence. New Phytologist 229 (2), 692-711

2020

12. Ma S*, Lapin D*, Liu L*, Sun Y*, Song W*, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science 370 (6521), eabe3069

2019

13. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z, Jiang K, Guo H.  (2019) A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis. Journal of Biological Chemistry 294 (52), 19923-19933

2018

14. Qian P*, Song W*, Yokoo T, Minobe A, Wang G, Ishida T, Sawa S, Chai J, Kakimoto T. (2018) The CLE9/10 secretory peptide regulates stomatal and vascular development through distinct receptors. Nature Plants 4 (12), 1071-1081

2017

15. Song W, Han Z, Wang J, Lin G, Chai J. (2017) Structural insights into ligand recognition and activation of plant receptor kinases. Current Opinion in Structural Biology 43, 18-27

16. Wu Z*, Liang S*, Song W*, Lin G, Wang W, Zhang H, Han Z, Chai J. (2017) Functional and structural characterization of a receptor-like kinase involved in germination and cell expansion in Arabidopsis. Frontiers in Plant Science 8, 1999

2016

17. Song W*, Liu L*, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z, Guo H, Chai J. (2016) Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Research 26 (6), 674-685

18. Zhang H, Han Z, Song W, Chai J. Structural insight into recognition of plant peptide hormones by receptors. (2016) Molecular Plant 9 (11), 1454-1463

2015

19. Song W*, Wang J*, Han Z*, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J, Wang HW, Chai J. (2015) Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature Structural & Molecular Biology 22 (10), 782-787

20. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J, Wang H, Wang J. (2015) An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein & Cell (12), 919-923

2014

21. Song W, Han Z, Sun Y, Chai J. (2014) Crystal structure of a plant leucine rich repeat protein with two island domains. Science China Life Sciences 57 (1), 137-144

22. Song W, Liu L, Li P, Sun H, Qin Y. (2014) Analysis of the mating and reproductive traits of Plutella xylostella (Lepidoptera: Plutellidae). Journal of Insect Science 14 (1)

2013

23. Song W, Li H, Song F, Liu L, Wang P, Xun H, Dai X, Chang J, Cai W. (2013) The complete mitochondrial genome of a tessaratomid bug, Eusthenes cupreus (Hemiptera: Heteroptera: Pentatomomorpha: Tessaratomidae). Zootaxa 3620 (2), 260-272

获奖情况

2013年中国农业大学优秀毕业生

2016年河南省科技进步一等奖

2018年清华大学优秀毕业生