题目：白血病干细胞功能稳态调控机制研究

主讲人：张好建

时间：2020年4月8日（星期四）上午9：30

地点：生命科学研究中心2018会议室

联系人：于舒洋            联系方式：62733810

主讲人简介

张好建，现为武汉大学免疫与代谢前沿科学中心／医学研究院教授，博士生导师。入选第十一批国家高层次人才青年项目，现主持国家自然科学基金优秀青年基金。

主要研究方向：造血干细胞功能维持的调控机制、白血病致病机理、白血病干细胞干性维持以及耐药的分子机理等方面的探索。以第一或通讯作者在Cell Stem Cell (2016; 2020)，Nature Genetics，Blood等杂志发表多篇论文。曾获得2016年哈佛大学华人学者生命科学杰出研究奖、2013年美国Leukemia & Lymphoma Society Fellow奖 。

代表论著：

1. Mengdie Feng#, Xueqin Xie#, Guoqiang Han#, Tiantian Zhang, Yashu Li, Yicun Li, Rong Yin, Qifan Wang, Tong Zhang, Peipei Wang, Jin Hu, Ying Cheng, Zhuying Gao, Jing Wang, Jiwei Chang, Manman Cui, Kexin Gao, Jihua Chai, Weidong Liu, Chengli Guo, Shaoguang Li, Lingbo Liu, Fuling Zhou, Jianjun Chen, Haojian Zhang*. YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner. Blood. 2021 (IF= 17.543)

2. Jiazhen Wang#,Yicun Li#, Peipei Wang#, Guoqiang Han#, Tiantian Zhang, Jiwei Chang, Rong Yin, Yi Shan, Jin Wen, Xueqin Xie, Mengdie Feng, Qifan Wang, Jin Hu, Ying Cheng, Tong Zhang, Yashu Li, Zhuying Gao, Chengli Guo, Jiang Wang, Jianfei Liang, Manman Cui, Kexin Gao, Jihua Chai, Weidong Liu, Hui Cheng, Lei Li, Fuling Zhou, Lingbo Liu, Yi Luo, Shaoguang Li, Haojian Zhang* Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell. 2020 (IF= 20.86)

3. Haojian Zhang, David Kozono, Kevin O’Connor, Sofia Vidal-Cardenas, Alix Rousseau, Abigail Hamilton, Lisa Moreau, Emily Gaudiano, Joel Greenberger, Grover Bagby, Jean Soulier, Markus Grompe, Kalindi Parmar, Alan D. D’Andrea*. TGF-β Inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia. Cell Stem Cell. 2016 (IF= 20.86)

4. Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia Miron, Xueqing Zhang, Michael A Brehm, Dongguang Li, Michael R Green, Shaoguang Li*. Tumor suppressor role of the Blk pathway in cancer stem cells of chronic myeloid leukemia. Nature Genetics. 2012 (IF= 27.603)

5. Haojian Zhang, Huawei Li, Hualin S Xi, Shaoguang Li*. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood. 2012 (IF=17.543)

   欢迎各位老师同学参加！