教师简介
姓名: | 毕国志 | |
性别: | 男 |
系别: | 微生物学与免疫学 |
职称: | 教授 |
学位: | 博士 |
毕国志 博士,教授,博士生导师,2022年以“杰出人才”引进中国农业大学。
学习与工作经历:
2022/4-至今,中国农业大学生物学院,教授
2020/11-2022/3,中国科学院遗传与发育生物学研究所,副研究员
2015/7-2020/11,中国科学院遗传与发育生物学研究所,博士后
2012/9-2015/4,Wageningen大学,联培博士
2011/9-2015/7,东北农业大学,农学博士学位
2008/9-2011/7,东北农业大学,农学硕士学位
2004/9-2008/7,东北农业大学,农学学士学位
研究方向:
植物病害是制约农作物生产的重要因素之一。本实验室主要研究方向为植物与病原微生物互作。一方面以拟南芥为实验材料,综合运用分子生物学、遗传学和生物化学等手段,解析信号分子活性氧调控植物免疫的分子机制,深入理解免疫信号网络,为植物抗病的分子设计提供新靶标和新策略。另一方面以玉米为研究材料,通过正向、反向遗传学,分离及鉴定玉米抗病基因,并阐明分子机制,为培育抗病新品种提供重要的基因资源。
联系方式
电话:18801230035
邮件:guozhibi at cau.edu.cn
通讯地址:北京市海淀区圆明园西路2号中国农业大学生物学院,邮编:100193
代表性文章 (#共同第一作者,*通讯作者)
1. Bi G#*, Hu M#, Fu L#, Zhang X, Zuo J, Li J, Yang J*, Zhou J-M*. (2022) The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay, Nat Plants, 8: 1160–1175
2. Bi G#, Su M#, Li N#, Liang Y, Dang S, Xu J, Hu M, Wang J, Zou M, Deng Y, Li Q, Huang S, Li J, Chai J*, He K*, Chen Y-H*, Zhou J-M*. (2021) The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling, Cell, 184: 3528-3541
3. Bi G, Zhou J-M. (2021) Regulation of cell death and signaling by pore-forming resistosomes, Annu Rev Phytopathol, 59: 239-263
4. Hu M#, Qi J#, Bi G*, Zhou J-M*. (2020) Bacterial effectors induce oligomerization of immune receptor ZAR1 in vivo, Mol Plant, 13: 793-801
5. Bi G#, Zhou Z#, Wang W#, Li L, Rao S, Wu Y, Zhang X, Menke F, Chen S, Zhou J-M. (2018) Receptor-like cytoplasmic kinases directly link diverse pattern recognition receptors to the activation of mitogen-activated protein kinase cascades in Arabidopsis, Plant Cell, 30: 1543-1561
6. Bi G, Zhou J-M. (2017) MAP kinase signaling pathways: a hub of plant-microbe interactions, Cell Host Microbe, 21: 270-273
7. Bi G, Liebrand T, Bye R, Postma J, Burgh A, Robatzek S, Xu X*, Joosten M*. (2016) SOBIR1 requires the GxxxG dimerization motif in its transmembrane domain to form constitutive complexes with receptor-like proteins, Mol Plant Pathol, 17: 96-107
部分合作文章
1. Yuan M, Jiang Z, Bi G, Nomura K, Liu M, Wang Y, Cai B, Zhou J-M, He S, Xin X-F.(2021) Pattern-recognition receptors are required for NLR-mediated plant immunity, Nature, 592: 105-109
2. Zhou Z, Zhao Y, Bi G, Liang X, Zhou Jian-Min. (2019) Early signalling mechanisms underlying receptor kinase-mediated immunity in plants, Philos Trans R Soc Lond B Biol Sci, 374: 20180310
3. Zhou Z, Bi G, Zhou Jian-Min; Luciferase complementation assay for protein-protein interactions in plants, Curr Protoc plant Biol, 2018, 3(1): 42-50
4. Liang X, Ma M, Zhou Z, Wang J, Yang X, Rao S, Bi G, Li L, Zhang X, Chai J, Chen S, Zhou J-M. (2018) Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases, Cell Res, 28(5): 529-543
5. Wu J, Burgh A, Bi G, Zhang L, Alfano J, Martin G, Joosten M. (2018) The bacterial effector AvrPto targets the regulatory co-receptor SOBIR 1 and suppresses defence signalling mediated by the receptor-like protein Cf-4, Mol Plant Microbe Interact, 31(1): 75-85
6. Rao S, Zhou Z, Miao P, Bi G, Hu M, Wu Y, Feng F, Zhang X, Zhou J-M. (2018) Roles of receptor-like cytoplasmic kinase VII members in pattern-triggered immune signaling, Plant Physiol, 177: 1679-16903.
7. Postma J, Liebrand T, Bi G, Evrard A, Bye R, Mbengue M, Kuhn H, Joosten M, Robatzek S. (2016) Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity, New Phytol, 210: 627-642
承担项目及课题
主持国家自然科学基金委青年科学基金项目和面上项目。